An observational study in Breast Cancer, sponsored by National Cancer Research Network. Status unknown at 9 sites in United Kingdom. Open to female participants aged Up to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-08-12.
Sponsored by National Cancer Research Network · Observational
RATIONALE: Gathering information about genetic changes in patients with lobular carcinoma in situ of the breast may help doctors learn more about the disease and find better methods of treatment.
PURPOSE: This clinical trial is studying the genetics of women with lobular carcinoma in situ of the breast.
OBJECTIVES:
Primary
Secondary
OUTLINE: Patients and control participants undergo blood collection. DNA is extracted from blood samples and used to genotype at selected polymorphisms, compare allele frequencies (used to associate alleles with disease) using a genome-wide single nucleotide polymorphism (SNP) screen. Archival tumor samples (if available) from patients are used for DNA-, RNA-, or protein-based analyses.
All participants complete a questionnaire about family history, a brief medical history, and provide epidemiological data to a genetic counselor. Participants identified to be at risk for known hereditary predisposition to cancer will be referred to a clinical genetics service. Individual results of this study are not disclosed to participants.
Peer Reviewed and Funded or Endorsed by Cancer Research UK.
PROJECTED ACCRUAL: A total of 2,000 participants (1,000 patients and 1,000 matched controls) will be accrued for this study.
6,745 studies on the registry are indexed under Carcinoma; 1,163 are open to participants now.
This study's planned enrollment of 3,000 is above the median of 149 across 1,175 observational studies indexed under Carcinoma.
Browse Carcinoma studies →This is the only study on the registry with National Cancer Research Network as lead sponsor.
Counted across the registry records on this site, refreshed daily.
DISEASE CHARACTERISTICS:
Meets 1 of the following criteria:
Current or prior diagnosis of lobular carcinoma in situ (LCIS) of the breast, including any of the following cases:
Control participant matched for age and ethnicity to each LCIS patient
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Inherited variation predisposing development of lobular carcinoma in situ (LCIS) of the breast in women
Frequency and effect of variants on tumor risk
Clinical setting variant test value in identifying, counseling and screening those women at higher risk
LCIS genetic changes which may progress to invasive cancer
This study is status unknown, as verified in Sep 2007. You cannot join it, but the record below documents what was studied.
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