CClinicalTrials.gg
CompletedNCT00532896Updated Feb 22, 2012

Impact of Weight Loss Following Bariatric Surgery on Pulmonary Function in Patients With Morbid Obesity

An observational study in Bariatric Surgery, Obesity and Respiratory Diseases, sponsored by Laval University. Completed at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2012-02-22.

Sponsored by Laval University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
60
Ages
18 Years and older
Sex
All
01

Study summary

Increase in body mass index (BMI)is associated with a decrease in expiratory flows.Obesity is also associated with an increased prevalence of asthma.Consequences of obesity on respiratory function and on bronchial responsiveness are still to be documented.

This study aims to evaluate, before and after surgery, the impact of a bariatric surgery (biliopancreatic diversion with duodenal switch)on respiratory function in patients with morbid obesity .

Our hypothesis is that weight loss following bariatric surgery will induce significant improvements in pulmonary function and airway responsiveness, and, as a consequence, a reduction in respiratory symptoms,these changes being correlated with a reduction in systemic markers of inflammation. Maintenance of weight loss after one year will permit the persistence of these improvements

Read the detailed description

Patients will be evaluated before the surgery (time zero), 6 months and one year after their surgery. A control group of patients on a waiting list for bariatric surgery will be evaluated at time zero and after 6 months and one year.

At each visit,patients will:

  • fill a standardized respiratory questionnaire and a questionnaire on sleep apnea; questionnaires on asthma control will be completed by patients with asthma.
  • have a spirometry, pulmonary volumes measures by body plethysmography and methacholine inhalation test with evaluation of symptoms perception.
  • an induced sputum will be performed.
  • A blood sample will be drawn to evaluate inflammation and measure C-reactive protein concentration in plasma.
  • An allergy skin prick test will be done at time zero.
02

Conditions studied

03

In context

Respiratory Tract Diseases

617 studies on the registry are indexed under Respiratory Tract Diseases; 111 are open to participants now.

This study's enrollment of 60 is below the median of 294 across 216 observational studies indexed under Respiratory Tract Diseases.

Browse Respiratory Tract Diseases studies →

Lead sponsor

Laval University is the lead sponsor of 371 studies on the registry; 68 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Subjects on the waiting list for bariatric surgery at Laval Hospital will be offered to participate to the study.

Inclusion criteria

  • Body mass index >or= 35 kg/m2
  • Non-smokers or ex-smokers (\<10 packs-year)

Exclusion criteria

Exclusion Criteria:

  • Previous bariatric surgery
  • previous vagotomy
  • no compliance to visits
  • subjects unable to provide an informed consent or to understand the questions included in questionnaires
  • Patients with cardiac pacemaker
  • hemodynamically significant valvulopathy
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
60 participants (actual)
Biospecimen retention
Samples without dna

Groups and cohorts

  • bariatric surgery

    patients with morbid obesity undergoing a bariatric surgery

  • No bariatric surgery

    patients with morbid obesity on a waiting list for a bariatric surgery but who will have their surgery in more than one year.

06

Study locations

1 site
  • Centre de Recherche, Hôpital Laval
    Québec, Quebec G1V 4G5, Canada
07

References and documents

Publications

  • Boulet LP, Turcotte H, Martin J, Poirier P. Effect of bariatric surgery on airway response and lung function in obese subjects with asthma. Respir Med. 2012 May;106(5):651-60. doi: 10.1016/j.rmed.2011.12.012. Epub 2012 Feb 10. PubMed 22326605 ↗
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 22, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00532896
Lead sponsor
Laval University
Responsible party
Louis-Philippe Boulet (MD, FRCPC, FCCP, Laval University) — Principal investigator
First posted
Sep 21, 2007
Start date
Apr 2006
Primary completion
Jan 2011
Completion
May 2011
Last update
Feb 22, 2012

Study contacts

Louis-Philippe Boulet, MD
principal investigator · Hôpital Laval

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2012. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion