Prevention of Recurrent Aphthous Stomatitis Using Vitamins

• Patients willing and able to provide written informed consent for the study
• Patients with a history of at least three episodes of minor recurrent aphthous stomatitis (RAS) within the past one year

Exclusion Criteria:

• Patients with a history of other forms of RAS (major, herpetiform)
• Patients who will be using any other vitamins/supplements during the study or those who have used any vitamins/supplements on a regular basis during the 90 days immediately preceding enrollment onto the study (regular use is defined as continuous daily use for at least a two week period)
• Patients who are under the age of 18
• Women who are pregnant or nursing or those who plan to become pregnant
• Patients with a history of gout, kidney stones or iron overload disease
• Patients who currently smoke tobacco products
• Patients who are former smokers who have quit smoking within the past 30 days
• Patients with sulfite allergy
• Patients with a history of any systemic condition associated with oral ulceration. These include: Behcet's syndrome, Sweet's syndrome, Celiac disease, Crohn's disease, ulcerative colitis, HIV infection/AIDS, cyclic neutropenia and PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis)
• Patients on medications commonly associated with causing oral ulceration. These include nicorandil, methotrexate and chemotherapeutic agents used for cancer.
• Patients using oral topical anti-inflammatory agents during the course of the study
• Patients who plan to use any products specifically for management of RAS lesions
• Patients who are routinely using agents that could have an impact on duration of RAS lesions (e.g., antibacterial mouthrinses)
• Patients receiving any other investigational agent during the course of ths study
• Patients with any other condition that might preclude participation in the study in the opinion of the study investigators