An interventional study of Lorazepam and Diazepam in Alcohol Withdrawal, sponsored by Stanford University. Completed at 2 sites in United States. Open to participants aged 19 Years and older. Per ClinicalTrials.gov, last updated 2007-08-31.
Sponsored by Stanford University · Not applicable, Interventional, and Treatment
The purpose of this study is to compare the efficacy of two commonly used medications in the treatment of alcohol withdrawal, diazepam and lorazepam.
Despite the frequent use of benzodiazepines for the treatment of alcohol withdrawal, studies comparing the efficacy of long and short half-life benzodiazepines in the treatment of alcohol withdrawal have shown mixed results. Due to the conflicting nature of published reports, clinicians have no clear indication as to which type of agent is preferable. The purpose of this study is to compare the efficacy of two commonly accepted medications in the treatment of alcohol withdrawal, diazepam and lorazepam, which are long and short half-life benzodiazepines, respectively.
Stanford University is the lead sponsor of 2,161 studies on the registry; 428 are open to participants now.
Of its 268 completed or terminated interventional studies of FDA-regulated products, 207 (77%) have results posted.
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Exclusion Criteria:
Drug: Diazepam
Drug: Lorazepam
Lorazepam 1 to 2 mg by mouth or intravenously every two hours as needed for alcohol withdrawal symptoms.
Also known as: Ativan
Diazepam 20 mg by mouth every two hours x 3 doses, or for parenteral treatment, diazepam 10 mg intravenously every one hour x 6 doses. Give additional diazepam 10 mg by mouth or intravenously every two hours as needed for alcohol withdrawal symptoms.
Also known as: Valium
The primary outcome measures include serial measures of vital signs and scores on the Clinical Institute Withdrawal Assessment for Alcohol-Revised scale (CIWA-Ar), a widely used scale that monitors alcohol withdrawal symptoms.
Time frame: one to two weeks
Secondary outcome measures include total benzodiazepine use.
Time frame: one to two weeks
The record gives a start of May 2003 and a completion of Nov 2004. It does not say whether these dates are actual or estimated.
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This study is completed, as verified in Aug 2007. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Lorazepam · Diazepam