A Study for Patients With Complicated Skin and Skin Structure Infections

• Complicated skin and skin structure infection, presumed or proven to be caused by gram-positive pathogen(s).
• Patients, ages 18 years and older, must not be below normal body weight or morbidly obese.
• Female patients must not be pregnant at time of enrollment and must agree to a reliable method of birth control during the study and for 6 months following the last dose of study drug.

Exclusion Criteria:

Patients:

• with a condition which would prevent performing protocol safety and efficacy assessments.
• who have received antibiotics for more than 24 hours within the last 3 days.
• with an infection involving deep tissues or unlikely to be caused by gram positive bacteria
• who are nursing and will not stop nursing for at least 6 months
• with a prior allergic reaction to glycopeptides (e.g. vancomycin)

• with any of the following:

  1. toxic shock syndrome or toxic-like syndrome
  2. presumed or proven infection caused by Clostridium species
  3. bone infections
  4. ischemic or gangrenous ulcers or wounds
  5. infections caused only by gram-negative bacteria
  6. infection of an artificial joint that cannot be removed
  7. infection of the scrotum, perineum or perianal region
  8. infection of a severe burn wound
  9. severe ear infection involving bone and/or cartilage
  10. infection following injury in water possibly containing Vibrio species or following a history of eating raw oysters within 1 week prior to disease onset