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CompletedNCT00506805Updated May 28, 2012

Safety And Pharmacology Study Of SNX-5422 Mesylate In Subjects With Refractory Solid Tumor Malignancies

A Phase 1 interventional study of SNX-5422 in Cancer, sponsored by Esanex Inc.. Completed at 2 sites in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2012-05-28.

Sponsored by Esanex Inc. · Phase 1, Interventional, and Treatment

Phase
Phase 1
Study type
Interventional
Enrollment
44
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

Hsp90 is a chemical in the body that is involved in promotion of cancer. SNX-5422 is an experimental drug that blocks Hsp90. It is being evaluated for safety and efficacy in patients with cancer.

02

Conditions studied

  • Cancer

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Keywords

  • solid tumor malignancy; Hsp90
03

In context

Neoplasms

9,365 studies on the registry are indexed under Neoplasms; 2,489 are open to participants now.

This study's enrollment of 44 is below the median of 50 across 7,253 interventional studies indexed under Neoplasms.

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Lead sponsor

Esanex Inc. is the lead sponsor of 12 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • >18 years old
  • histologically confirmed solid tumor malignancy
  • refractory to available therapy or for which no therapy is available
  • adequate organ function

Exclusion criteria

Exclusion Criteria:

  • CNS malignancy
  • significant GI disease
  • at risk for prolonged QT interval
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
44 participants (actual)

Study arms

  • Experimental
    Single Arm

    Drug: SNX-5422

Interventions

  • DrugSNX-5422

    dose escalated, tablets every other day; undetermined duration until disease progression

06

What researchers measure

Primary outcomes

  1. adverse events and other safety assessments

    Time frame: continuous

Secondary outcomes

  1. tumor response measured by X-rays or scans

    Time frame: after every 2 cycles

07

Study locations

2 sites
  • Pfizer Investigational Site
    Scottsdale, Arizona 85258, United States
  • Pfizer Investigational Site
    Nashville, Tennessee 37203, United States
08

References and documents

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 28, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00506805
Lead sponsor
Esanex Inc.
Collaborators
Serenex, Inc., Pfizer
Responsible party
Sponsor
First posted
Jul 25, 2007
Start date
Jun 2007
Primary completion
Mar 2010
Completion
Mar 2010
Last update
May 28, 2012

Study contacts

Pfizer CT.gov Call Center
study director · Pfizer

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2012. You cannot join it, but the record below documents what was studied.

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