A Phase 1 interventional study of abdominal hot compress in Healthy, sponsored by University Hospital Freiburg. Completed at 1 site in Germany. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2007-06-12.
Sponsored by University Hospital Freiburg · Phase 1, Interventional, and Supportive care
We investigated, whether abdominal hot compresses effect hepatic blood flow. Our hypothesis was, that the hot compresses might either by local vasomotor-reflex or by decreasing the tone of the sympathetic nerve system increase hepatic blood flow.
Abdominal hot compresses are traditionally used by patients with liver diseases as self help. This study investigated the effect of abdominal hot compresses on hepatic blood flow measured by elimination of indocyanine green (ICG), a non-toxic green dye. It was presumed, that abdominal hot compresses increase hepatic blood flow either by local vasomotor-reflex or by decreasing the tone of the sympathetic nerve system.
In healthy volunteers ICG elimination was measured with and without hot compress at two investigations in a weekly interval. At each investigation ICG was injected as bolus after a rest period of 10 minutes. After the injection blood was taken in regular intervals for analysis of ICG concentration over a period of 40 minutes and half life was calculated.
The time interval between the investigations was 8 days, the sequence was randomly assigned.
University Hospital Freiburg is the lead sponsor of 91 studies on the registry; 18 are open to participants now.
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Exclusion Criteria:
Indocyanine green half life
Time frame: 40 minutes
heart rate, blood pressure
Time frame: 40 minutes
This study is completed, as verified in Jun 2007. You cannot join it, but the record below documents what was studied.
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University Hospital Freiburg