An interventional study of Somatropin and pegvisomant in Metabolism and Fatty Liver, sponsored by University of Aarhus. Completed at 1 site in Denmark. Open to male participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2008-08-12.
Sponsored by University of Aarhus · Not applicable, Interventional, and Basic science
The purpose of this study is to examine the effects of growth hormone during fasting in healthy lean men.
During fasting the human body is known to metabolize relatively large amounts of fat, in the expense of proteins and glucose. Partly this shift in metabolism is caused by increasing GH secretion, but exactly how growth hormone exerts these effects remains to be further investigated.
10 healthy lean young men are studied at 4 different occasions in a randomized single-blinded cross-over study. 1: after 12 hours of fasting + GH bolus, 2: after 36 hours of fasting + GH bolus, 3: after 36 hours + saline, 4: after 36 hours of fasting + Somavert.
Aim:
1,451 studies on the registry are indexed under Fatty Liver; 292 are open to participants now.
This study's enrollment of 10 is below the median of 60 across 1,003 interventional studies indexed under Fatty Liver.
Browse Fatty Liver studies →University of Aarhus is the lead sponsor of 1,274 studies on the registry; 183 are open to participants now.
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Exclusion Criteria:
12 hours of fasting and a GH bolus
Drug: Somatropin and pegvisomant
36 hours of fasting and a GH bolus
Drug: Somatropin and pegvisomant
36 hours of fasting and Pegvisomant
Drug: Somatropin and pegvisomant
36 hours of fasting and NaCl injection
Drug: Somatropin and pegvisomant
Somatropin are given intravenous, 0.5mg pegvisomant are given subcutaneous, 15 mg NaCl are given subcutaneous, 2 ml
changes in intrahepatic lipid content
Time frame: 12 and 36 hours of fasting. respectively
changes in intracellular signaling during fasting
Time frame: 36 hours
changes in respiratory quotient
Time frame: 36 hours of fasting
metabolism
Time frame: 36 hours of fasting
insulin sensitivity
Time frame: 36 hours of fasting
forearm metabolism
Time frame: 36 hours of fasting
changes in FFA
Time frame: 36 hours of fasting
Changes in grelin
Time frame: 36 hours of fasting
changes in leptin, adiponektin, cortisol, catecholamine, glucagon, carbamide, palmitate
Time frame: 36 hours of fasting
This study is completed, as verified in Aug 2008. You cannot join it, but the record below documents what was studied.
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University of Aarhus