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TerminatedNCT00453258Updated Jan 17, 2013

Pilot Study of Human Tear Proteins

An observational study in Eye Disease, sponsored by University of Colorado, Denver. Terminated at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-01-17.

Sponsored by University of Colorado, Denver · Observational

Why this study was terminated
Stopped due to low enrollment
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
63
Ages
18 Years and older
Sex
All
01

Study summary

The significance of our study is in the importance of understanding the quality and quantity of proteins in the human tear film from diseased and non-diseased patients. This pilot study will provide data to plan prospective research to better delineate the utility of tear proteins in diagnosing and following disease status in a non-invasive fashion.

02

Conditions studied

  • Eye Disease

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Keywords

  • ocular proteomics
  • eye disease
  • proteomics
03

In context

Eye Diseases

740 studies on the registry are indexed under Eye Diseases; 117 are open to participants now.

This study's enrollment of 63 is below the median of 120 across 172 observational studies indexed under Eye Diseases.

Browse Eye Diseases studies →

Lead sponsor

University of Colorado, Denver is the lead sponsor of 1,499 studies on the registry; 315 are open to participants now.

Of its 139 completed or terminated interventional studies of FDA-regulated products, 89 (64%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Subjects receiving eye examination

Inclusion criteria

  • 18 years of age and older
  • able to cooperate with tear sample collection
  • provide written informed consent

Exclusion criteria

Exclusion Criteria:

  • special populations (children, pregnant or lactating females, prisoners, etc)
  • refusal to sign sudy consent
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
63 participants (actual)
Patient registry
No

Groups and cohorts

  • Study Subject

    Subjects receiving eye examination

    Other: Eye Examination

Interventions

  • OtherEye Examination

    Subjects receiving eye examination

06

What researchers measure

Primary outcomes

  1. Plan Prospective Research

    Pilot study will provide data to plan prospective research to better delineate the utility of tear proteins in diagnosing and following disease status in a non-invasive fashion.

    Time frame: Throughout study participation

07

Study locations

1 site
  • Rocky Mountain Lions Eye Institute
    Aurora, Colorado 80045, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 17, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00453258
Lead sponsor
University of Colorado, Denver
Responsible party
Sponsor
First posted
Mar 28, 2007
Start date
Feb 2007
Primary completion
Sep 2011
Completion
Sep 2011
Last update
Jan 17, 2013

Study contacts

Malik Y. Kahook, MD
principal investigator · Rocky Mountain Lions Eye Institute

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Oct 2012. You cannot join it, but the record below documents what was studied.

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