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CompletedNCT00410618Updated Jul 6, 2018

Neurological Effects of Chemotherapy and Radiation Therapy in Patients With Colon Cancer

An observational study in Cognitive/Functional Effects, Colorectal Cancer and Long-term Effects Secondary to Cancer Therapy in Adults, sponsored by University of Arizona. Completed at 1 site in United States. Per ClinicalTrials.gov, last updated 2018-07-06.

Sponsored by University of Arizona · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
42
Sex
All
01

Study summary

RATIONALE: Learning about the long-term effects of chemotherapy and radiation therapy on brain function may help doctors plan cancer treatments.

PURPOSE: This clinical trial is looking at the neurological effects of chemotherapy and radiation therapy in patients with colon cancer.

Read the detailed description

OBJECTIVES:

Primary

  • Identify the nature and long-term ramifications of CNS injury as a result of cancer treatment in patients with colon cancer.

Secondary

  • Analyze differences in cognitive measures and MRI data in these patients.
  • Correlate MRI measures with cognitive performance in these patients.

OUTLINE: Patients undergo cognitive performance assessment and MRI.

PROJECTED ACCRUAL: A total of 42 patients will be accrued for this study.

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Conditions studied

  • Cognitive/Functional Effects
  • Colorectal Cancer
  • Long-term Effects Secondary to Cancer Therapy in Adults

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Keywords

  • cognitive/functional effects
  • long-term effects secondary to cancer therapy in adults
  • recurrent colon cancer
  • stage I colon cancer
  • stage II colon cancer
  • stage III colon cancer
  • stage IV colon cancer
03

In context

Colonic Neoplasms

1,432 studies on the registry are indexed under Colonic Neoplasms; 357 are open to participants now.

This study's enrollment of 42 is below the median of 280 across 349 observational studies indexed under Colonic Neoplasms.

Browse Colonic Neoplasms studies →

Lead sponsor

University of Arizona is the lead sponsor of 466 studies on the registry; 87 are open to participants now.

Of its 47 completed or terminated interventional studies of FDA-regulated products, 29 (62%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Colon cancer

Eligibility criteria

DISEASE CHARACTERISTICS:

  • Diagnosis of colon cancer
  • Received chemotherapy and radiotherapy for colon cancer

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
42 participants (actual)

Interventions

  • Procedurecognitive assessment
  • Proceduremagnetic resonance imaging
  • Proceduremanagement of therapy complications
06

What researchers measure

Primary outcomes

  1. Nature and long-term ramifications of CNS injury as a result of cancer treatment

Secondary outcomes

  1. Differences in cognitive measures and MRI data

  2. Relationship between MRI measures and cognitive performance

07

Study locations

1 site
  • Arizona Cancer Center at University of Arizona Health Sciences Center
    Tucson, Arizona 85724-5024, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 6, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00410618
Lead sponsor
University of Arizona
Collaborators
National Cancer Institute (NCI)
Responsible party
Sponsor
First posted
Dec 13, 2006
Start date
Apr 2003
Primary completion
Aug 2006
Completion
Aug 2006
Last update
Jul 6, 2018

Study contacts

Sheryl Reminger, MD
study chair · University of Arizona
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2012. You cannot join it, but the record below documents what was studied.

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