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CompletedNCT00410111Updated Oct 16, 2008

Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

An observational study in Sepsis, sponsored by University Hospital, Basel, Switzerland. Completed at 1 site in Switzerland. Open to participants aged 16 Years and older. Per ClinicalTrials.gov, last updated 2008-10-16.

Sponsored by University Hospital, Basel, Switzerland · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
23
Ages
16 Years and older
Sex
All
01

Study summary

Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown. We will investigate whether patients who develop this condition have different patterns of cerebrovascular reactivity and whether it is possible to predict the development of septic encephalopathy from early measurements of cerebral perfusion or from the EEG. We will specifically test the hypotheses that septic encephalopathy may not be predicted by changes in the EEG, and that cerebrovascular autoregulation is not dysfunctional in septic encephalopathy.

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Conditions studied

  • Sepsis

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Keywords

  • sepsis
  • encephalopathy
  • cerebral perfusion
  • electroencephalogram
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In context

Brain Diseases

758 studies on the registry are indexed under Brain Diseases; 202 are open to participants now.

This study's enrollment of 23 is below the median of 100 across 265 observational studies indexed under Brain Diseases.

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Lead sponsor

University Hospital, Basel, Switzerland is the lead sponsor of 968 studies on the registry; 191 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
16 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with sepsis, severe sepsis or septic shock admitted to an intensive care unit

Inclusion criteria

  • Sepsis
  • Admission to ICU

Exclusion criteria

Exclusion Criteria:

  • CNS infection
  • History of cerebrovascular disease
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
23 participants (actual)
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Study locations

1 site
  • Operative Intensivbehandlung, University of Basel Hospital
    Basel, 4031, Switzerland
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References and documents

Publications

  • Pfister D, Siegemund M, Dell-Kuster S, Smielewski P, Ruegg S, Strebel SP, Marsch SC, Pargger H, Steiner LA. Cerebral perfusion in sepsis-associated delirium. Crit Care. 2008;12(3):R63. doi: 10.1186/cc6891. Epub 2008 May 5. PubMed 18457586 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 16, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00410111
Lead sponsor
University Hospital, Basel, Switzerland
First posted
Dec 12, 2006
Start date
Jan 2007
Completion
Jul 2007
Last update
Oct 16, 2008

Study contacts

Luzius A Steiner, MD PhD
principal investigator · Department of Anesthesia, University of Basel Hospital, Basel, Switzerland
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2008. You cannot join it, but the record below documents what was studied.

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