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RecruitingNCT00373841GAPUpdated Aug 27, 2026

Genomic and Proteomic Analysis of Disease Progression in Idiopathic Pulmonary Fibrosis (IPF)

An observational study in Idiopathic Pulmonary Fibrosis, sponsored by University of Pittsburgh. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-27.

Sponsored by University of Pittsburgh · Observational

Study type
Observational
Model
Cohort
Time perspective
Other
Enrollment
500
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of the study is to identify genetic and biologic markers that may predict the loss of lung function due to idiopathic pulmonary fibrosis. The studies will compare genetic and biologic markers of samples to changes in symptoms. The ultimate goal is to predict if or when patients are likely to experience a rapid decline in lung function due to disease progression.

Read the detailed description

People who are diagnosed with idiopathic pulmonary fibrosis are asked to participate in this study. The subject must be treated at the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease. Subjects, if consented, are required to perform tests so that research data can be collected. At the initial visit, patients are subject to having a blood draw, pulmonary function testing, echocardiograms, and CT scans as well as completing several questionnaires designed to measure how the patient is feeling. Follow up visits are then scheduled in 3-4 month intervals. Every 3-4 months blood samples will be collected while every 6-8 months the questionnaires will administered. If the patient enters a stage of accelerated decline in lung function, a bronchoscopy will be performed to collect residual bronchoalveolar lavage fluid for testing. All of the results of clinical and laboratory testing will be placed into the subjects research file.

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Conditions studied

  • Idiopathic Pulmonary Fibrosis

Keywords

  • Lung
  • Fibrosis
  • Idiopathic
  • Biomarkers
  • Genomics
  • Longitudinal
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In context

Idiopathic Pulmonary Fibrosis

576 studies on the registry are indexed under Idiopathic Pulmonary Fibrosis; 123 are open to participants now.

This study's planned enrollment of 500 is above the median of 152 across 165 observational studies indexed under Idiopathic Pulmonary Fibrosis.

Browse Idiopathic Pulmonary Fibrosis studies →

Lead sponsor

University of Pittsburgh is the lead sponsor of 1,419 studies on the registry; 168 are open to participants now.

Of its 9 completed or terminated interventional studies of FDA-regulated products, 4 (44%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients aged 18 and older who have been diagnosed with IPF and referred by a Simmons Center doctor.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients who are 18 or older
  • Diagnosis of Idiopathic Pulmonary Fibrosis
  • Treated at the Simmons Center

Exclusion criteria

Exclusion Criteria:

  • Other Lung Illness
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Study design

Observational model
Cohort
Time perspective
Other
Enrollment
500 participants (estimated)
Biospecimen retention
Samples with dna
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Study locations

1 of 1 sites recruiting
  • Michelle F MacPherson
    Pittsburgh, Pennsylvania 15213, United States
    Recruiting
    • Michelle F MacPherson, MAT · Contactmacphersonmj@upmc.edu · 14126474537
    • Michelle L Meyers, BSN RN · Contactmeyersma@upmc.edu · 412-692-2149
    • Luis Ortiz, MD · Sub investigator
    • Prabhir Ray, PhD · Sub investigator
    • Yingze Zhang, PhD · Sub investigator
    • Kristen Veraldi, M.D. · Sub investigator
    • Daniel J. Kass, M.D. · Sub investigator
    • Michelle F. MacPherson, BS, MAT · Sub investigator
    • Michelle Meyers, BSN, RN · Sub investigator
    • Kevin F Gibson, MD · Principal investigator
    • Morgan L Carnahan, BS · Sub investigator
    • Daniel Sullivan, MD · Sub investigator
    • Eleanor Valenzi, MD · Sub investigator
    • Seyed Mehdi Nouraie, MD · Sub investigator
    • Xiaoping Chen, MS · Sub investigator
    • Gillian Goobie, MD PhD · Sub investigator
    • John Sembrat, PhD · Sub investigator
    • Timothy Corcoran, PhD · Sub investigator
    • Xiaoyun Li, MD · Sub investigator
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References and documents

Publications

  • Chien JW, Richards TJ, Gibson KF, Zhang Y, Lindell KO, Shao L, Lyman SK, Adamkewicz JI, Smith V, Kaminski N, O'Riordan T. Serum lysyl oxidase-like 2 levels and idiopathic pulmonary fibrosis disease progression. Eur Respir J. 2014 May;43(5):1430-8. doi: 10.1183/09031936.00141013. Epub 2013 Oct 31. PubMed 24177001 ↗
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Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Oct 2005, a primary completion of Jul 2030 and a completion of Jul 2030. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 6, 2006
First posted
Sep 8, 2006
Start
Oct 2005
Primary completionEst.
Jul 2030
CompletionEst.
Jul 2030
Last update
Aug 27, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 27, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00373841
Responsible party
Kevin F. Gibson (Professor of Medicine, University of Pittsburgh) — Principal investigator
First posted
Sep 8, 2006
Start date
Oct 2005
Primary completion
Jul 2030 (estimated)
Completion
Jul 2030 (estimated)
Last update
Aug 27, 2026

Study contacts

Michelle MacPherson, MAT
Contact
macphersonmj@upmc.edu
412-647-4537
Michelle Meyers, BSN RN
Contact
meyersma@upmc.edu
412-692-2149
Kevin F Gibson, MD
principal investigator · University of Pittsburgh - Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

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