An observational study in Non-Hodgkin's Lymphoma, sponsored by National Cancer Institute (NCI). Completed at 4 sites in United States. Open to participants aged 20 Years to 74 Years. Per ClinicalTrials.gov, last updated 2020-11-27.
Sponsored by National Cancer Institute (NCI) · Observational
Non-Hodgkin's lymphoma (NHL) incidence rates have risen three percent per year in the U.S. for four decades. Mortality from NHL has risen 1.6 percent, compared with 0.2 percent for all cancers combined. This epidemic curve appears in both sexes and around the world, suggesting the possibility of an etiologic agent increasing in prevalence in the general environment. Recent research has identified several possible candidates including pesticides, other organochlorines, drinking water nitrates, and sunlight. There is an urgent need to evaluate whether these common exposures are contributing to the rapid rise in NHL, and to investigate other hypothesized risk factors such as viruses, medical conditions, hair dye use, and genetic factors. The purpose of this study is to examine the contribution to NHL risk of these important environmental, occupational, viral, medical, and personal exposures, and to pursue important leads emerging from on-going NHL research. This multidisciplinary, population-based case-control study will involve personal interviews to collect information on demographics, residential history, pesticide use, and occupational exposures; self-administered questionnaires to collect information on diet, family and medical history, and other exposures; tap water and carpet dust sampling to collect information on nitrate and pesticide exposures; and blood sampling for measurements of compounds in the serum, antibodies to viruses, and examination of genetic polymorphisms.
Non-Hodgkin's lymphoma (NHL) incidence rates have risen three percent per year in the U.S. for four decades. Mortality from NHL has risen 1.6 percent, compared with 0.2 percent for all cancers combined. This epidemic curve appears in both sexes and around the world, suggesting the possibility of an etiologic agent increasing in prevalence in the general environment. Recent research has identified several possible candidates including pesticides, other organochlorines, drinking water nitrates, and sunlight. There is an urgent need to evaluate whether these common exposures are contributing to the rapid rise in NHL, and to investigate other hypothesized risk factors such as viruses, medical conditions, hair dye use, and genetic factors. The purpose of this study is to examine the contribution to NHL risk of these important environmental, occupational, viral, medical, and personal exposures, and to pursue important leads emerging from on-going NHL research. This multidisciplinary, population-based case-control study will involve personal interviews to collect information on demographics, residential history, pesticide use, and occupational exposures; self-administered questionnaires to collect information on diet, family and medical history, and other exposures; tap water and carpet dust sampling to collect information on nitrate and pesticide exposures; and blood sampling for measurements of compounds in the serum, antibodies to viruses, and examination of genetic polymorphisms.
5,578 studies on the registry are indexed under Lymphoma; 825 are open to participants now.
This study's enrollment of 2,378 is above the median of 136 across 625 observational studies indexed under Lymphoma.
Browse Lymphoma studies →National Cancer Institute (NCI) is the lead sponsor of 3,506 studies on the registry; 334 are open to participants now.
Of its 402 completed or terminated interventional studies of FDA-regulated products, 365 (91%) have results posted.
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Residents of participating SEER registries
Women and men residing in the areas served by the four SEER registries.
Individuals between the ages of 20 and 74 (ages between 20 and 64 must live in households with telephones).
Individuals who have a first primary diagnosis of NHL after April 1, 1998 to July 1, 1998.
Individuals must be HIV negative.
EXCLUSION CRITERIA:
Individuals must not be previously diagnosed with NHL.
individuals diagnosed with incident, first primary non-Hodgkin lymphoma
individuals identified in the same geographical areas without non-Hodgkin lymphoma or othercancers
No intervention. Observational study compares cases and controls.
non-Hodgkin lymphoma cases versus controls
Time frame: at the time of enrollment
This study is completed, as verified in Nov 2020. You cannot join it, but the record below documents what was studied.
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National Cancer Institute (NCI)