A Phase 4 interventional study of vitamin C & E supplements in Heliobacter Pylori Infection, sponsored by University of Toronto. Status unknown at 1 site in Canada. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2007-08-14.
Sponsored by University of Toronto · Phase 4, Interventional, and Prevention
This study argues that H.pylori infection, by increasing the production of reactive oxygen species, increases the utilization of dietary antioxidants(Vit E and Vit C) that serve in quenching the free radicals, thus decreasing their serum levels and confounding their protective effect against gastric cancer.
It has been postulated that dietary antioxidants may reduce cancer risk by modulating red-ox status, by preventing biological oxidation, and by inhibiting the formation of carcinogen. However, supplementation studies and prospective studies have yielded contradictory results. In the case of gastric cancer, H.pylori infection, which is known to be associated with a higher risk of the disease, results in an increased production of ROS \& RNS. As a result serum levels of these free radicals increase, exerting a higher demand for dietary antioxidants to neutralize them.
The fact that the relation between serum levels of antioxidants and gastric cancer is more consistent than that of dietary intake levels and the disease suggests the possibility of the presence of an intrinsic factor that is altering the true relation between dietary antioxidants and the cancer. This intrinsic factor, this study argues, is the infection with H.pylori.
H.pylori infection, by increasing the production of reactive oxygen species, increases the utilization of dietary antioxidants that serve in quenching the free radicals, thus decreasing their serum levels and confounding their protective effect against gastric cancer. The purpose of this pilot study is to investigate the possibility that H.pylori infection alters the bioavailability of the dietary antioxidants: vitamin C, and vitamin E. This project will be done in preparation for an etiologic study of dietary antioxidants and gastric cancer.
6,687 studies on the registry are indexed under Infections; 807 are open to participants now.
This study's planned enrollment of 72 is below the median of 120 across 4,200 interventional studies indexed under Infections.
Browse Infections studies →University of Toronto is the lead sponsor of 397 studies on the registry; 59 are open to participants now.
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Exclusion Criteria:
plasma vitamin C levels
plasma vitamin E levels
TBARS levels
This study is status unknown, as verified in Aug 2007. You cannot join it, but the record below documents what was studied.
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