An observational study in Post-Traumatic Stress Disorders, Anxiety and Amnesia, Dissociative, sponsored by University Hospital, Tours. Completed at 1 site in France. Open to female participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-03-17.
Sponsored by University Hospital, Tours · Observational
Neuropsychological studies investigating trauma-exposed and posttraumatic stress disorder (PTSD) subjects have generally underlined the significantly poorer performance of tasks that require attention, concentration, and verbal memory, and difficulty in regulating memories surrounding the traumatic event. A previous study (El Hage et al. Cognitive Neuropsychiatry, 2006) revealed that the trauma-exposed subjects scored higher on anxiety/depression scales, and lower on processing speed tests. Moreover, the study showed significant impairment in working memory partially mediated by speed processing, but not by anxiety or depression. These results suggest that processing speed makes a major contribution to trauma-related working memory decline, and needs to be investigated in further studies.The aim of the present study is to explore correlation between hippocampus volume, frontal dysfunction and cognitive slowing in trauma-exposed subjects, while examining brain activation during performance of working memory tasks using functional magnetic resonance.
Working memory performance will be assessed using the "3-back test", and processing speed evaluated with "words comparison test". The study will be conducted on 2 years. The study should include 18 right-handed females victims of sexual abuse and suffering from PTSD, and 18 controls right-handed females without any history of abuse ad not suffering from PTSD. Brain activation will be measured during performance of working memory tasks (3-back test) and processing speed test using functional magnetic resonance.
2,682 studies on the registry are indexed under Stress Disorders, Post-Traumatic; 601 are open to participants now.
This study's enrollment of 34 is below the median of 150 across 371 observational studies indexed under Stress Disorders, Post-Traumatic.
Browse Stress Disorders, Post-Traumatic studies →University Hospital, Tours is the lead sponsor of 307 studies on the registry; 79 are open to participants now.
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PTSD related to sexual abuse vs controls, in right-handed females.
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Exclusion Criteria:
Procedure: Magnetic Resonance Imaging, Functional
Procedure: Magnetic Resonance Imaging, Functional
Structural and functional MRI
The record gives a start of Jan 2007, a primary completion of May 2008 and a completion of May 2008. It does not say whether these dates are actual or estimated.
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This study is completed, as verified in Mar 2010. You cannot join it, but the record below documents what was studied.
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Stress Disorders, Post-Traumatic →