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CompletedNCT00262418Updated Dec 28, 2007

Comparison of the Efficacy and Safety of Ivermectin to Permethrin

A Phase 2 interventional study of Administration of ivermectin or permethrin in Scabies, sponsored by University Ghent. Completed at 1 site in Belgium. Open to participants aged 5 Years and older. Per ClinicalTrials.gov, last updated 2007-12-28.

Sponsored by University Ghent · Phase 2, Interventional, and Treatment

Phase
Phase 2
Study type
Interventional
Enrollment
160
Allocation
Randomized
Ages
5 Years and older
Sex
All
01

Study summary

Comparison of the efficacy and safety of a single administration of ivermectin to a single administration of permethrin for the treatment of scabies

Read the detailed description

Administration of ivermectin or permethrin on day0 Clinical examination and pictures on day0, day14 and day28 Blood sample on day0 VAS for pruritus, DLQI and SF-36 on day0, day14 and day28

02

Conditions studied

  • Scabies

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03

In context

Scabies

51 studies on the registry are indexed under Scabies; 10 are open to participants now.

This study's enrollment of 160 is below the median of 183 across 41 interventional studies indexed under Scabies.

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Lead sponsor

University Ghent is the lead sponsor of 350 studies on the registry; 86 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
5 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

At least one of the following inclusion criteria:

  • Scabies tunnels
  • Positive microscopic examination (acarids, faeces or ova)

At least two of the three following inclusion criteria:

  • Non-specific injuries with a typical distribution pattern
  • Serious itching which increases during the night
  • Family or contacts with similar complaints

Exclusion criteria

Exclusion Criteria:

  • Treatment for scabies \< 4 weeks ago
  • Treatment with corticoids \< 1 week ago
  • Pregnancy
  • Breast-feeding
  • Serious immunodepressive patients
  • Sensitivity or allergy to one of the components of the study medication
  • Damage of the central nerve system
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

HIV

The human immunodeficiency virus, which weakens the immune system.

Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.

05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Single group
Masking
Double
Enrollment
160 participants (actual)

Interventions

  • DrugAdministration of ivermectin or permethrin
06

What researchers measure

Primary outcomes

  1. Clinical healing of the skin injuries

    Time frame: on day28

Secondary outcomes

  1. Decrease of itching

    Time frame: on day28

  2. Amelioration of the life quality

    Time frame: on day28

  3. Number and gravity of adverse events

07

Study locations

1 site
  • University Hospital Ghent
    Ghent, 9000, Belgium
08

References and documents

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 28, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00262418
Lead sponsor
University Ghent
First posted
Dec 6, 2005
Start date
Jul 2004
Completion
May 2005
Last update
Dec 28, 2007

Study contacts

Jean-Marie Naeyaert, MD, PhD
principal investigator · University Hospital, Ghent

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2007. You cannot join it, but the record below documents what was studied.

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