CClinicalTrials.gg
CompletedNCT00259246Updated Jan 21, 2009

The Role of Peptide YY (PYY)Infusions in Inhibiting Food Intake.

An interventional study of Peptide YY infusion in Obesity, sponsored by University of Copenhagen. Completed. Open to male participants aged 20 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-01-21.

Sponsored by University of Copenhagen · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
24
Allocation
Randomized
Ages
20 Years to 50 Years
Sex
Male
01

Study summary

The aim of the study is to compare fasting and postprandial PYY levels between overweight/obese and lean subjects during and after an infusion of saline, PYY1-36 or PYY3-36 and to evaluate the efects on appetite, energy intake and energy expenditure.

Read the detailed description

The study is a randomised dobbelblinded placebo controlled study with 24 male subjects ( 12 lean and 12 overweight/obese subjects). VAS scores are used to assess appetite and two ad libitum meals are served in the hours following the infusion. Energy expenditure is measured by ventilated hood system and blood is sampled during part of the study day.

02

Conditions studied

  • Obesity
03

In context

Lead sponsor

University of Copenhagen is the lead sponsor of 450 studies on the registry; 61 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 50 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • Normal weight (BMI: 18-23 kg/m2) or 12 overweight/obese (BMI: 27-40 kg/m2)
  • Body weight fluctuations \< 5 kg over the past 2 months.
  • Blood pressure normal to mildly hypertensive (\<159/99 mm Hg)
  • Non-elite athletes and not planning to change physical activity during the study.

Exclusion criteria

Exclusion Criteria:

  • Any physiological or psychological illnesses that could influence the study results
  • Regular use of medicine
  • Smoking defined as \<1 cigarette per day.
  • Substance abuse or dependence.
  • Blood donation within the past 3 months before entering the study
  • Drinking >21 alcoholic units/week.
  • Food allergies.
  • Special diets (e.g. vegetarian) or dislikes to any of the foods served during the study.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single
Enrollment
24 participants

Interventions

  • DrugPeptide YY infusion
06

What researchers measure

Primary outcomes

  1. Appetite

  2. Energy intake

Secondary outcomes

  1. Energy expenditure and substrate oxidation

  2. Blood parameters

  3. Blood pressure and heart rate

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 21, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00259246
Lead sponsor
University of Copenhagen
Collaborators
EC-FP6 (contract number: LHM-CT-2003-503041), Aditech Pharma AB
First posted
Nov 29, 2005
Start date
Jun 2004
Completion
Nov 2005
Last update
Jan 21, 2009

Study contacts

Arne Astrup, Professor
principal investigator · Department of Human Nutrition, RVAU
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2005. You cannot join it, but the record below documents what was studied.

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