An interventional study of Regulating Mean Arterial Pressure during cardiopulmonary bypass in Coronary Artery Bypass Graft Surgery, sponsored by Weill Medical College of Cornell University. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2008-04-11.
Sponsored by Weill Medical College of Cornell University · Not applicable, Interventional, and Prevention
It is the long term objective of this study to preserve or improve the quality of life and to prevent deterioration in physical and mental function following myocardial revascularization among bypass surgery patients.
The objective of this study is to compare the efficacy of two strategies of intra-operative hemodynamic management in preventing peri-operative cardiac, cognitive and neurologic morbidity and mortality and postoperative deterioration in the patient's quality of life.
Weill Medical College of Cornell University is the lead sponsor of 890 studies on the registry; 163 are open to participants now.
Of its 123 completed or terminated interventional studies of FDA-regulated products, 94 (76%) have results posted.
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In this group (Low) the goal was to maintain MAP between 50-60 mm Hg during CPB.
Procedure: Regulating Mean Arterial Pressure during cardiopulmonary bypass
In this group (High), the goal was to maintain MAP between 80-100 mm Hg during CPB.
Procedure: Regulating Mean Arterial Pressure during cardiopulmonary bypass
Patients were randomized to one of two groups. In the first group (Low) the goal was to maintain MAP between 50-60 mm Hg during CPB. In the second group (High), the goal was to maintain MAP between 80-100 mm Hg. In both groups, CPB flow was held constant at 1.6 L/min/M2 (cool) and 2.4 L/min/M2 (warm) and vasoactive drugs (nitroglycerin or phenylephrine) were used to maintain MAP in the desired range. MAP was controlled in this fashion from the onset of CPB through separation from CPB began.
Also known as: Mean Arterial Pressure during cardiopulmonary bypass 50-60 mm/Hg (control) vs. 80-100 mm/Hg (experimental)
Cardiac morbidity
Time frame: 6-months after surgery
Neurologic morbidity
Time frame: 6-months after surgery
Mortality
Time frame: 6-months after surgery
Functional status
Time frame: 6-months after surgery
Neurocognitive function
Time frame: 6-months after surgery
This study is completed, as verified in Apr 2008. You cannot join it, but the record below documents what was studied.
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Weill Medical College of Cornell University →