CClinicalTrials.gg
Sign In
CompletedNCT00228306Updated May 1, 2012

The Effect of Aerobic Exercise on Learning After Stroke

A Phase 1 interventional study of Rehabilitation exercise in Stroke, sponsored by University of Kansas. Completed at 1 site in United States. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2012-05-01.

Sponsored by University of Kansas · Phase 1, Interventional, and Treatment

Phase
Phase 1
Study type
Interventional
Enrollment
38
Allocation
Randomized
Ages
18 Years to 85 Years
Sex
All
01

Study summary

Determine if attaining aerobic fitness is beneficial in producing cortical neuroplasticity in individuals with chronic stroke.

Read the detailed description

Crossover clinical trial. Experimental group undergoes 3x/wk/6 months of aerobic conditioning. Control group performs usual daily activities. All participants will be assessed with cognitive and motor behavioral testing at baseline, 3, 6, 9 and 12 months.

02

Conditions studied

  • Stroke

Browse trials for

03

In context

Stroke

7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.

This study's enrollment of 38 is below the median of 50 across 5,369 interventional studies indexed under Stroke.

Browse Stroke studies →

Lead sponsor

University of Kansas is the lead sponsor of 81 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 85 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Single ischemic stroke occuring 6-72 months prior
  • Fugl-Meyer score (upper + lower extremity) 45 or greater
  • Mini mental status score of >23
  • approval of the subject's medical doctor

Exclusion criteria

Exclusion Criteria:

  • already performing >20 min of cardiovascular exercise 3x/wk or more
  • alcohol consumption of >2 oz. liquor, 8 oz. wine or 24 oz beer/day
  • cardiac history of unstable angina, recent myocardia infarction within the last 3 months, congestive heart failure, significant valve dysfunction
  • medical history of recent hospitalization (> 3 months) for medical illness
  • symptomatic peripheral arterial occlusive disease
  • orthopedic or chronic pain conditions restricting exercise
  • pulmonary or renal failure
  • active cancer
  • unstable hypertension (>160/100 mmHg)
  • diabetes mellitus (fasting glucose > 180 NG./dk, HgA1C > 10%) that is unable to be controlled \< month
  • receptive or expressive aphasia as indicated on MMSE
  • multiple strokes or other neuromuscular conditions
  • major depression that is untreated using the Beck depression inventory
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Participant)
Enrollment
38 participants (actual)

Study arms

  • Experimental
    1

    Behavioral: Rehabilitation exercise

  • No intervention
    2

    Control Group

Interventions

  • BehavioralRehabilitation exercise

    Rehab therapy is delivered for 8 weeks.

06

What researchers measure

Primary outcomes

  1. Motor learning behavioral measures; executive function behavioral measures.

    Time frame: Baseline, 8 weeks, 12 weeks

Secondary outcomes

  1. Peak V02 and other aerobic capacity measures. Physical disability measures.

    Time frame: Baseline, 8 weeks, 12 weeks

07

Study locations

1 site
  • University of Kansas Medical Center
    Kansas City, Kansas 66160, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 1, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00228306
Lead sponsor
University of Kansas
Collaborators
American Heart Association
Responsible party
Sponsor
First posted
Sep 28, 2005
Start date
Sep 2005
Primary completion
Dec 2008
Completion
Dec 2009
Last update
May 1, 2012

Study contacts

Barbara Quaney, PT, PhD
principal investigator · University of Kansas Medical Center

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2012. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Other studies in this condition

Stroke→

Other studies from this sponsor

University of Kansas

Start the discussion