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CompletedNCT00222391Updated Jan 7, 2009

Influence of Thoracic Epidural Anesthesia on Skin Sympathetic Activity and Heart Rate Variability

An observational study in Abdominal Surgery and Abdominothoracic Surgery, sponsored by University Hospital Muenster. Completed at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2009-01-07.

Sponsored by University Hospital Muenster · Observational

Study type
Observational
Time perspective
Prospective
Enrollment
40
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of the study is to evaluate the impact of epidural anesthesia on sympathetic activity in surgical patients. The study investigates whether a segmental sympathetic block can be determined and can be correlated to level of the sensoric blockade.

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Conditions studied

  • Abdominal Surgery
  • Abdominothoracic Surgery
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In context

Lead sponsor

University Hospital Muenster is the lead sponsor of 189 studies on the registry; 18 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • elective surgery
  • combined anesthesia with thoracic epidural anesthesia 8 (Th6-9
  • Body-mass-index \< 30

Exclusion criteria

Exclusion Criteria:

  • Fever, Hypothermia, SIRS
  • Microangiopathy
  • Neuropathy
  • Sensomotoric deficits
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Study design

Time perspective
Prospective
Enrollment
40 participants
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What researchers measure

Primary outcomes

  1. Hemodynamic parameters

Secondary outcomes

  1. Level of sensoric block

  2. skin temperature

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Study locations

1 site
  • Department of Anesthesia and Intensive Care, University Hospital Muenster
    Muenster, D-48149, Germany
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References and documents

Publications

  • Freise H, Meissner A, Lauer S, Ellger B, Radke R, Bruewer M, Brodner G, Van Aken HK, Sielenkamper AW, Fischer LG. Thoracic epidural analgesia with low concentration of bupivacaine induces thoracic and lumbar sympathetic block: a randomized, double-blind clinical trial. Anesthesiology. 2008 Dec;109(6):1107-12. doi: 10.1097/ALN.0b013e31818db16c. PubMed 19034108 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 7, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00222391
Lead sponsor
University Hospital Muenster
First posted
Sep 22, 2005
Start date
Apr 2004
Completion
Jan 2006
Last update
Jan 7, 2009

Study contacts

Henrik Freise, MD
principal investigator · Department of Anesthesiology and Intensive Care, University Hospital Münster
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2006. You cannot join it, but the record below documents what was studied.

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