Pelvic Exenteration in Treating Patients With Recurrent Cervical Cancer

Inclusion Criteria:

• Diagnosis of cervical cancer

  • Any histology
  • Documented or suspected central pelvic disease with or without pelvic sidewall fixation from tumor and/or radiation fibrosis

• Meets 1 of the following stage criteria:

  • Recurrent disease, defined as reappearance of disease after a complete clinical response lasting ≥ 1 month
  • Persistent disease, defined as presence of disease by biopsy ≥ 3 months after completion of primary therapy

• Must have received prior primary treatment, including any of the following:

  • Surgery with or without post operative radiotherapy with or without chemotherapy
  • Primary radiotherapy with or without chemotherapy
  • Neoadjuvant chemotherapy followed by surgery
  • Neoadjuvant chemotherapy followed by surgery with or without radiotherapy or chemotherapy

• Plans to undergo pelvic exenteration to remove the pelvic disease within 14 days after study entry

  • Deemed to be a good surgical candidate

    • No evidence of distant disease or disease that is felt to be unresectable by physical examination
    • Patients with suspicious pelvic or para-aortic nodal disease as the only site(s) of extrapelvic disease are eligible at the discretion of the surgeon
  • Patients whose surgery is planned solely for managing complications (e.g., rectovaginal fistula, vesicovaginal fistula) of disease or prior therapy are not eligible
  • Patients whose surgery is planned as a prophylactic measure due to a slow or suboptimal clinical or radiographical tumor response during the course of primary therapy are not eligible
• No distant site of metastases by CT scan or MRI of the abdomen/pelvis OR positron-emission tomography
• No noncervical primary tumor
• No prior anterior or posterior pelvic exenteration