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CompletedNCT00216853Updated Apr 16, 2009

A Study of Vaginal MicroFlora and Immune Profiles of Patients With Recurrent Urinary Tract Infection

An observational study in Urinary Tract Infections, sponsored by London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's. Completed at 1 site in Canada. Open to female participants aged 20 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-04-16.

Sponsored by London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
44
Ages
20 Years to 80 Years
Sex
Female
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Study summary

The purpose of this study is to determine the extent to which vaginal microflora and immune profiles of patients with urinary tract infection (UTI) differ from healthy controls.

Read the detailed description

Recurrent urinary tract infections, which occur mostly in the female population, can be potentially harmful if not treated and significantly reduce quality of life. By characterizing the vaginal microflora and immune profiles of women that suffer recurrent UTIs in contrast to a healthy age matched normal group of women (with no history of recurrent UTIs), we can better understand the differences. This in turn can lead to development of better quality probiotics that will be based on their scientific basis, clinical efficacy, and quality in terms of shelf life and delivery to target sites. The reduction in only one third of UTI cases seen each year would have a significant impact on reducing health care costs.

02

Conditions studied

03

In context

Infections

6,687 studies on the registry are indexed under Infections; 807 are open to participants now.

This study's enrollment of 44 is below the median of 240 across 2,136 observational studies indexed under Infections.

Browse Infections studies →

Lead sponsor

London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's is the lead sponsor of 352 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 80 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Eligibility criteria

Inclusion Criteria:

Inclusion Criteria for UTI Group:

  1. At least 2 recurrent UTIs within the last year
  2. Written informed consent

Inclusion Criteria for Normal Group:

  1. No UTI within the past 5 years
  2. Written informed consent

Exclusion Criteria:

Exclusion Criteria for Both Groups:

  1. Active UTI
  2. Urinary tract anomalies
  3. Evidence of a neurogenic bladder
  4. Known immunodeficiencies
  5. Use of antibiotics, within the last month
  6. Concomitant use of oral steroids
  7. Known renal calculi
  8. Previous or ongoing chemotherapy
  9. Pregnancy
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
44 participants (actual)

Groups and cohorts

  • Patients with Recurrent UTI
  • Healthy controls
06

Study locations

1 site
  • St. Joseph's Health Centre
    London, Ontario, Canada
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 16, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT00216853
Lead sponsor
London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's
Collaborators
Natural Sciences and Engineering Research Council, Canada
First posted
Sep 22, 2005
Start date
Sep 2003
Primary completion
Jun 2006
Completion
Mar 2007
Last update
Apr 16, 2009

Study contacts

Stephen Pautler, MD, FRCSC
principal investigator · London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2009. You cannot join it, but the record below documents what was studied.

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