An interventional study of galantamine in Parkinson's Disease, sponsored by Memorial Hospital of Rhode Island. Status unknown at 1 site in United States. Open to participants aged 60 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2007-05-07.
Sponsored by Memorial Hospital of Rhode Island · Not applicable, Interventional, and Prevention
The aim of the study is to determine whether galantamine stabilizes or improves thinking abilities in individuals with Parkinson's disease. Individuals included in the study have minor complaints about thinking such as problems with concentration or memory but do not have dementia. This medication has been shown to have a positive effect on stabilizing memory in individuals with Alzheimer's disease. It is FDA approved for use in elderly individuals with Alzheimer's disease. It is hypothesized that galantamine will stabilize or improve executive and attentional functions in individuals with Parkinson's.
While several cholinesterase inhibitors have effectiveness in Alzheimer's disease (AD), galantamine is unique since it has a dual mode of action: inhibition of acetylcholinesterase and modulation of nicotinic acetylcholine receptors.As Parkinson's disease (PD) impacts frontal systems, executive cognition rather than memory function (mediated by medial temporal) would be the targeted area for potential improvement. This single center, double blind, placebo controlled study compares a group of PD patients treated with galantamine to a group of PD patients who are not treated with this medication on a series of cognitive tasks that examine attention and executive control.
4,583 studies on the registry are indexed under Parkinson Disease; 1,097 are open to participants now.
This study's planned enrollment of 90 is above the median of 40 across 3,365 interventional studies indexed under Parkinson Disease.
Browse Parkinson Disease studies →Memorial Hospital of Rhode Island is the lead sponsor of 10 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Improvement on cognitive measures
Time frame: 16 weeks
No worsening of PD symptoms
Time frame: 16 weeks
This study is status unknown, as verified in May 2007. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Galantamine
Memorial Hospital of Rhode Island