An observational study in Heart Failure With Preserved Ejection Fraction, sponsored by Brigham and Women's Hospital. Completed at 1 site in United States. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2007-11-09.
Sponsored by Brigham and Women's Hospital · Observational
This study will test the hypothesis that increases in ventricular-vascular stiffness can be demonstrated by arterial tonometry and echocardiography in subjects with heart failure with preserved ejection fraction (HF-nlEF)(i.e. normal left ventricular function.) We will also track changes in pulsatile hemodynamics over time in subjects hospitalized with HF-nlEF.
The pathophysiologic mechanisms responsible for the development of heart failure in people with preserved ejection fraction (i.e. normal left ventricular function) remain poorly understood. One possible mechanism may be the contribution of increased arterial stiffness to changes in pulsatile hemodynamic load during ventricular systole, implicating abnormal ventricular-vascular interactions throughout the cardiac cycle in the pathogenesis of heart failure with normal ejection fraction.
To investigate changes in ventricular-vascular stiffness in subjects with heart failure and normal left ventricular function, comparisons will be made between 3 distinct sub-populations:
5,701 studies on the registry are indexed under Heart Failure; 1,220 are open to participants now.
This study's enrollment of 53 is below the median of 200 across 1,679 observational studies indexed under Heart Failure.
Browse Heart Failure studies →Brigham and Women's Hospital is the lead sponsor of 1,236 studies on the registry; 224 are open to participants now.
Of its 116 completed or terminated interventional studies of FDA-regulated products, 64 (55%) have results posted.
Counted across the registry records on this site, refreshed daily.
adults with heart failure and preserved left ventricular function
Subjects with heart failure and preserved ejection fraction
Diabetic subjects with hypertension
Normotensive control subjects
Exclusion Criteria:
Subjects with heart failure and preserved ejection fraction
Non-diabetic subjects with hypertension
Diabetic subjects with hypertension
Normotensive control subjects
subjects with heart failure and normal ejection fraction non-diabetic hypertensive controls hypertensive diabetic controls normotensive controls
Procedure: arterial tonometry · Procedure: echocardiography
used to determine peripheral arterial vascular tone by measuring blood pressure waveforms via a probe attached to the finger.
Also known as: PAT
ultrasound test using sound waves to create a moving picture of the heart
Also known as: cardiac echo
This study is completed, as verified in Nov 2007. You cannot join it, but the record below documents what was studied.
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Brigham and Women's Hospital