CClinicalTrials.gg
Status unknownNCT00192803Updated Feb 23, 2006

Non-Insulin Dependent Diabetes Mellitus (NIDDM) and Angiotensin Converting Enzyme 2 (ACE2): Diabetic Patients Treated With Antihypertensive Drugs

A Phase 4 interventional study of candesartan in NIDDM, sponsored by Rambam Health Care Campus. Status unknown at 1 site in Israel. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2006-02-23.

Sponsored by Rambam Health Care Campus · Phase 4, Interventional, and Educational/counseling/training

The sponsor has not verified this record recently (last verified Sep 2005), so the status shown — last known as Not yet recruiting — may be out of date.
Phase
Phase 4
Study type
Interventional
Enrollment
20
Allocation
Non-randomized
Ages
18 Years to 90 Years
Sex
All
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Study summary

This feasibility study is designed to examine modulation of the relative activities of ACE and ACE2 in diabetic patients following treatment with the angiotensin type 1 receptor (AT1R) antagonist, Candesartan.

This study will provide a closer insight to the possible involvement of the renin-angiotensin system (RAS)-related enzymatic components in development or attenuation of vascular pathogenesis.

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Conditions studied

  • NIDDM

Keywords

  • niddm
  • ace2
  • NIDDM patients
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In context

Diabetes Mellitus, Type 2

9,359 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,318 are open to participants now.

This study's enrollment of 20 is below the median of 80 across 7,525 interventional studies indexed under Diabetes Mellitus, Type 2.

Browse Diabetes Mellitus, Type 2 studies →

Lead sponsor

Rambam Health Care Campus is the lead sponsor of 456 studies on the registry; 33 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Signed informed consent
  • Non-smokers
  • Type II DM diagnosed patients
  • Blood pressure \< 135/90
  • Serum HbA1C > 7%
  • Serum creatinine \< 1mg%
  • Urine microalbumin \< 300 mg/day
  • Body mass index (BMI) \< 35 kg/m2

Exclusion criteria

Exclusion Criteria:

  • Insulin-dependent diabetic patients
  • Patient with persistent microalbuminuria
  • Patient with history of severe hypertension
  • Congestive heart failure
  • Patient receiving renin-angiotensin-aldosterone system (RAAS)-related anti-hypertensive medications.
  • Patient with major hepatic disease
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Study design

Phase
Phase 4
Primary purpose
Educational/counseling/training
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
20 participants

Interventions

  • Drugcandesartan
06

What researchers measure

Primary outcomes

  1. ACE and ACE2 activities in monocytes

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Study locations

1 site
  • Internal Ward "A", Rambam Medical Center
    Haifa, Israel
    • Ayelet Raz, MD · Contact · 972-4-8543072
    • Ayelet Raz, MD · Sub investigator
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 23, 2006, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00192803
Lead sponsor
Rambam Health Care Campus
First posted
Sep 19, 2005
Last update
Feb 23, 2006

Study contacts

Shlomo Keidar, MD
Contact
skeidar@rambam.health.gov.il
97248542518
Shlomo Keidar, MD
principal investigator · Rambam Health Care Campus
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Sep 2005. You cannot join it, but the record below documents what was studied.

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