An interventional study of Pentastarch (displace either 500 ml or 1000 ml of pump prime with pentastarch) in Cardiac Surgery and Cardiopulmonary Bypass, sponsored by Hamilton Health Sciences Corporation. Status unknown at 1 site in Canada. Per ClinicalTrials.gov, last updated 2007-09-20.
Sponsored by Hamilton Health Sciences Corporation · Not applicable, Interventional, and Treatment
Patients undergoing cardiac surgery with cardiopulmonary bypass require significant fluid administration. Fluids are used routinely to replace blood lost during and after surgery. Significant amounts of fluid are also used to prime the tubing and components of the cardiopulmonary bypass pump before and during its use. The use of Pentaspan - a synthetic pentastarch - was started because of the restriction of use for blood and blood products, particularly albumin. Pentaspan is usually used after surgery in the Intensive Care Unit (ICU). The impact of the use of pentastarch on coagulation, fluid balance and bleeding are very limited. This study will methodically evaluate the impact of using increasingly greater amounts of pentastarch during surgery on an open heart surgery patient's recovery in particular - is there more bleeding, does his/her blood clot as well, and how much fluid overall is used and excreted?
Hamilton Health Sciences Corporation is the lead sponsor of 237 studies on the registry; 35 are open to participants now.
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Exclusion Criteria:
transfusion requirements
fluid balance
postoperative bleeding
mediastinal drainage
coagulation parameters
respiratory status
This study is status unknown, as verified in Sep 2004. You cannot join it, but the record below documents what was studied.
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Hamilton Health Sciences Corporation