CClinicalTrials.gg
Status unknownNCT00180791Updated Sep 18, 2007

High Risk Primitive Neuroectodermal (PNET) Brain Tumors in Childhood

A Phase 2 interventional study of Etoposide, carboplatin, melphalan, cisplatin, thiotepa in Medulloblastoma, Brain Tumors and Neuroectodermal Tumors, Primitive, sponsored by Gustave Roussy, Cancer Campus, Grand Paris. Status unknown at 1 site in France. Open to participants aged Up to 10 Years. Per ClinicalTrials.gov, last updated 2007-09-18.

Sponsored by Gustave Roussy, Cancer Campus, Grand Paris · Phase 2, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Sep 2006), so the status shown — last known as Recruiting — may be out of date.
Phase
Phase 2
Study type
Interventional
Enrollment
71
Allocation
Non-randomized
Ages
Up to 10 Years
Sex
All
01

Study summary

The purpose of this study is to evaluate the efficacy of the combination of surgery, conventional chemotherapy, sequential high-dose chemotherapy with peripheral blood stem cell transplantation and reduced dose radiation therapy in high-risk PNET brain tumors.

02

Conditions studied

  • Medulloblastoma
  • Brain Tumors
  • Neuroectodermal Tumors, Primitive

Keywords

  • Brain PNET
03

In context

Neoplasms

9,365 studies on the registry are indexed under Neoplasms; 2,489 are open to participants now.

This study's planned enrollment of 71 is above the median of 50 across 7,253 interventional studies indexed under Neoplasms.

Browse Neoplasms studies →

Lead sponsor

Gustave Roussy, Cancer Campus, Grand Paris is the lead sponsor of 242 studies on the registry; 65 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Up to 10 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Medulloblastoma in patients less than 5 years of age
  • Brain PNET in patients less than 10 years of age
  • Histologically documented diagnosis
  • Body weight of > 8 kg

Exclusion criteria

Exclusion Criteria:

  • Parents' refusal
05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
71 participants (estimated)

Interventions

  • DrugEtoposide, carboplatin, melphalan, cisplatin, thiotepa
06

What researchers measure

Primary outcomes

  1. Response of medulloblastoma metastases to the chemotherapy regimen in children less than 5 years of age

  2. Progression-free survival of children less than 10 years of age with brain PNET

Secondary outcomes

  1. Progression-free survival of children less than 5 years of age with metastatic medulloblastoma

  2. Toxicity

  3. Long term sequelae

07

Study locations

1 of 1 sites recruiting
  • Institut Gustave Roussy
    Villejuif, 94800, France
    • Chantal Kalifa, MD · Contact · kalifa@igr.fr · 33 1 42 11 4166
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 18, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00180791
Lead sponsor
Gustave Roussy, Cancer Campus, Grand Paris
First posted
Sep 16, 2005
Start date
Jul 2002
Last update
Sep 18, 2007

Study contacts

Chantal Kalifa, MD
Contact
kalifa@igr.fr
33 1 42 11 4166
Agnès Laplanche, MD
Contact
laplanche@igr.fr
33 1 42 11 4127
Chantal Kalifa, MD
principal investigator · Gustave Roussy, Cancer Campus, Grand Paris
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Sep 2006. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion