CompletedNCT00169689Updated Jan 30, 2008

Repetitive Transcranial Magnetic Stimulation

An interventional study of rTMS, "repetitive transcranial magnetic stimulation" and rTMS in Schizophrenia, sponsored by Heinrich-Heine University, Duesseldorf. Completed at 1 site in Germany. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2008-01-30.

Sponsored by Heinrich-Heine University, Duesseldorf · Not applicable, Interventional, and Treatment

Phase: Not applicable
Study type: Interventional
Enrollment: 40
Allocation: Randomized
Ages: 18 Years to 60 Years
Sex: All

Study summary

The study is a prospective, randomized, double-blind sham-controlled study.

Read the detailed description

The principal objective of this trial is to investigate the effect of left prefrontal high frequency rTMS on negative symptoms in schizophrenia.

Conditions studied

Schizophrenia

Browse trials for

Schizophrenia 3,471

Keywords

schizophrenia, rTMS

In context

Schizophrenia

3,471 studies on the registry are indexed under Schizophrenia; 472 are open to participants now.

This study's enrollment of 40 is below the median of 70 across 2,872 interventional studies indexed under Schizophrenia.

Browse Schizophrenia studies →

Lead sponsor

Heinrich-Heine University, Duesseldorf is the lead sponsor of 174 studies on the registry; 52 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years to 60 Years
Sexes eligible: All
Accepts healthy volunteers: No

Inclusion criteria

DSM-IV criteria for schizophrenia
age between 18 and 60
informed consent
right handed patient
no change of antipsychotic treatment > 2 weeks before recruitment

Exclusion criteria

Exclusion Criteria:

seizures, epilepsy
history of severe head injury
status post implantation of a cardiac pacemaker or other electronic devi-ses

Study design

Phase: Not applicable
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel assignment
Masking: Triple (Participant, Care provider, Outcomes assessor)
Enrollment: 40 participants (actual)

Study arms

Sham comparator
rTMS
sham coil system versus verum rTMS stimulation
Procedure: rTMS, "repetitive transcranial magnetic stimulation" · Other: rTMS

Interventions

ProcedurerTMS, "repetitive transcranial magnetic stimulation"
10 Hz rTMS (10.000 stimuli) over left dorsolateral prefrontal cortex
OtherrTMS
repetitive transcranial magnetic stimulation, 10 Hz, 10.000 stimuli, 2 weeks

What researchers measure

Primary outcomes

Clinical Global Impression;
Time frame: November 2007

Secondary outcomes

Global psychosocial functioning (GAF), PANSS-Negative Subscale,changes in EEG, heart rate variability, cortisol daytime profile, catecholamines, cognitive functioning
Time frame: November 2007

Study locations

1 site

Joachim Cordes
Düsseldorf, Rhineland 40629, Germany

References and documents

Publications

Cordes J, Arends M, Mobascher A, Jänner M, Wölwer W, Krieger K, Agelink MW, Klimke A, Brinkmeyer J. Left prefrontal high frequency repetitive transcra-nial magnetic stimulation (rTMS) and the effect on schizophrenic psychopathol-ogy. European Archives of Psychiatry and Clinical Neuroscience 2004; Vol. 254, Suppl. 1: 11. Cordes J, Brinkmeyer J, Kotrotsios G, Arends M, Mobascher A, Agelink MW, Wölwer W. The effect of high frequency repetitive transcranial magnetic stimula-tion (rTMS) on negative symptoms and electrophysiological correlates of facial affect recognition in schizophrenia. Schizophrenia Bulletin 2005 b; 31 (2): 510.
Wolwer W, Lowe A, Brinkmeyer J, Streit M, Habakuck M, Agelink MW, Mobascher A, Gaebel W, Cordes J. Repetitive transcranial magnetic stimulation (rTMS) improves facial affect recognition in schizophrenia. Brain Stimul. 2014 Jul-Aug;7(4):559-63. doi: 10.1016/j.brs.2014.04.011. Epub 2014 May 9. PubMed 24857264 ↗
Cordes J, Thunker J, Agelink MW, Arends M, Mobascher A, Wobrock T, Schneider-Axmann T, Brinkmeyer J, Mittrach M, Regenbrecht G, Wolwer W, Winterer G, Gaebel W. Effects of 10 Hz repetitive transcranial magnetic stimulation (rTMS) on clinical global impression in chronic schizophrenia. Psychiatry Res. 2010 May 15;177(1-2):32-6. doi: 10.1016/j.psychres.2009.01.014. Epub 2010 Apr 8. PubMed 20378181 ↗

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Jan 30, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT00169689
Lead sponsor: Heinrich-Heine University, Duesseldorf
First posted: Sep 15, 2005
Start date: Jun 2003
Completion: Aug 2007
Last update: Jan 30, 2008

Study contacts

Joachim Cordes, MD

principal investigator · Department of Psychiatry and Psychotherapy at the Heinrich-Heine-University Düsseldorf,Rhineland State Clinics Düsseldorf, Bergische Landstraße 2, 40629 Düsseldorf, Germany

PD Dr. W Wölwer

principal investigator · Heinrich-Heine-University

PD Dr. MW Agelink

principal investigator · Department of Psychiatry Herford

Oversight

Data monitoring committee: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2008. You cannot join it, but the record below documents what was studied.

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