A Phase 1 interventional study of Tetanus-diphtheria toxoids (Td) and 7-valent pneumococcal conjugate vaccine in Pneumococcal Infections, sponsored by Centers for Disease Control and Prevention. Completed at 1 site in United States. Open to participants aged 50 Years to 64 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-03-14.
Sponsored by Centers for Disease Control and Prevention · Phase 1, Interventional, and Prevention
The purpose of this study is to learn whether or not giving a tetanus/diphtheria vaccination ("tetanus shot") before giving pneumococcal vaccine makes the pneumococcal vaccine more effective without causing too many side effects.
The only vaccine licensed in the United States for protecting adults against pneumococcal disease (PPV23) protects against invasive disease in observational studies but has generally been poorly effective against pneumonia or all-cause mortality in randomized clinical trials. Another vaccine containing seven polysaccharide antigens conjugated to diphtheria toxoid (PCV7) is licensed for children and under investigation in adults.
In this pilot study, we are comparing the safety and immunogenicity of three immunization schedules in adults:
We aim to:
286 studies on the registry are indexed under Pneumococcal Infections; 27 are open to participants now.
This study's enrollment of 30 is below the median of 365 across 234 interventional studies indexed under Pneumococcal Infections.
Browse Pneumococcal Infections studies →Centers for Disease Control and Prevention is the lead sponsor of 275 studies on the registry; 2 are open to participants now.
Of its 11 completed or terminated interventional studies of FDA-regulated products, 8 (73%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
ELISA for S. pneumoniae antibody 2 months after receiving PPV23
Functional S. pneumoniae antibody 2 months after receiving PPV23
Incidence of adverse events following vaccination from entry to 2 months after receiving last vaccination
This study is completed, as verified in Mar 2012. You cannot join it, but the record below documents what was studied.
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