An observational study in Bone Cancer, sponsored by University of Florida. Completed at 1 site in United States. Per ClinicalTrials.gov, last updated 2012-10-30.
Sponsored by University of Florida · Observational
This purpose of this study is to measure the strength of tissue allografts that have been in the body various lengths of time.
Allograft bone is the primary source of graft material for large skeletal defects resulting from trauma, disease, oncological resection, or reconstruction of failed total joint arthroplasties. The physical characteristics of such grafts after various intervals of remodeling and incorporation in vivo have never been studied.
The purpose of this study is to obtain tissue from allografts retrieved at autopsy, at amputation for oncological complications and from patients undergoing revision procedures for failed allograft transplantation. We will evaluate the mechanical properties, histomorphometric indices and presence of microfractures.
Our hypotheses are:
The retrieved tissue will be processed using standard undecalcified histology and quantitatively assessed for degree of incorporation, allograft porosity, and microfracture density. The biomechanical characteristics of the bulk allograft and allograft-host junction will be quantified and compared to allograft bone prior to transplantation.
322 studies on the registry are indexed under Bone Neoplasms; 81 are open to participants now.
This study's enrollment of 18 is below the median of 75 across 93 observational studies indexed under Bone Neoplasms.
Browse Bone Neoplasms studies →University of Florida is the lead sponsor of 1,254 studies on the registry; 201 are open to participants now.
Of its 170 completed or terminated interventional studies of FDA-regulated products, 136 (80%) have results posted.
Counted across the registry records on this site, refreshed daily.
Orthopaedic clinic
Exclusion Criteria:
Allograft constructs removed because of infection or cancer complications will be retained for biomechanical testing
This study is completed, as verified in Oct 2012. You cannot join it, but the record below documents what was studied.
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University of Florida