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CompletedNCT00154024Updated Sep 28, 2006

Comparison of Vascular Effects After Therapy With Irbesartan and Atorvastatin.

An interventional study of atorvastatin and irbesartan in Healthy Subjects, sponsored by Technische Universität Dresden. Completed at 1 site in Germany. Open to male participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2006-09-28.

Sponsored by Technische Universität Dresden · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
Male
01

Study summary

Vascular responses to angiotensin II and histamine are compared before and after 30 days of systemic treatment with either irbesartan 150 mg or atorvastatin 20 mg.

Read the detailed description

Vascular responses to angiotensin II and histamine are compared before and after 30 days of systemic treatment with either irbesartan 150 mg or atorvastatin 20 mg.

02

Conditions studied

  • Healthy Subjects

Keywords

  • venoconstriction
  • venodilation
  • pleiotropic effects
03

In context

Lead sponsor

Technische Universität Dresden is the lead sponsor of 237 studies on the registry; 45 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • healthy subjects
  • no relevant disease
  • amendment: hypercholesterolaemic subjects

Exclusion criteria

Exclusion Criteria:

  • any relevant disease
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double

Interventions

  • Drugatorvastatin
  • Drugirbesartan
06

What researchers measure

Primary outcomes

  1. vascular responses after treatment.

07

Study locations

1 site
  • Institute of Clinical Pharmacology, Medical Faculty, University of Technology
    Dresden, 01307, Germany
08

References and documents

Publications

  • Schindler C, Guenther K, Hermann C, Ferrario CM, Schroeder C, Haufe S, Jordan J, Kirch W. Statin treatment in hypercholesterolemic men does not attenuate angiotensin II-induced venoconstriction. PLoS One. 2014 Sep 29;9(9):e103909. doi: 10.1371/journal.pone.0103909. eCollection 2014. Erratum In: PLoS One. 2014;9(10):e112205. PubMed 25264877 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 28, 2006, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00154024
Lead sponsor
Technische Universität Dresden
First posted
Sep 12, 2005
Start date
Mar 2003
Completion
Oct 2006
Last update
Sep 28, 2006

Study contacts

Wilhelm Kirch, MD
study chair · Institute of Clinical Pharmacology
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2006. You cannot join it, but the record below documents what was studied.

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