An interventional study of rosiglitazone (drug) in Healthy Subjects, sponsored by Technische Universität Dresden. Completed at 1 site in Germany. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2006-09-12.
Sponsored by Technische Universität Dresden · Not applicable, Interventional, and Treatment
The study is designed to test the hypothesis in healthy subjects that the oral antidiabetic drug rosiglitazone provides additional vascular relaxing or modulating effects in addition to its blood glucose level reducing ability.
The aim of the study is to investigate the effect of oral rosiglitazone therapy on the vascular responsiveness of different vasoactive compounds (angiotensin II, insulin, histamine and glyceroltrinitrate) in healthy subjects. Rosiglitazone will be given orally (4 weeks 4mg/d, titrated to 8 mg/d for another 4 weeks) as treatment. Every subject will receive intravenous stimulation with angiotensin II, histamine, insulin and glyceroltrinitrate before and after an 8 weeks treatment interval with rosiglitazone.
Technische Universität Dresden is the lead sponsor of 237 studies on the registry; 45 are open to participants now.
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Exclusion Criteria:
Vascular reactivity after 8 weeks treatment.
Changes in angiotensin peptide metabolism.
This study is completed, as verified in Sep 2006. You cannot join it, but the record below documents what was studied.
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Technische Universität Dresden