CClinicalTrials.gg
CompletedNCT00116441Updated Dec 24, 2007

Vaccination in the Peripheral Stem Cell Transplant Setting for Multiple Myeloma

A Phase 1/2 interventional study of Therapeutic Cellular Vaccine, GM-CSF Producing in Multiple Myeloma, sponsored by Cell Genesys. Completed at 1 site in United States. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2007-12-24.

Sponsored by Cell Genesys · Phase 1/2, Interventional, and Treatment

Phase
Phase 1/2
Study type
Interventional
Enrollment
22
Allocation
Non-randomized
Ages
18 Years to 70 Years
Sex
All
01

Study summary

The purpose of this study is to evaluate the safety and efficacy of vaccination with autologous myeloma cells and an allogeneic granulocyte-macrophage colony stimulating factor (GM-CSF) producing cell line.

02

Conditions studied

  • Multiple Myeloma

Keywords

  • Multiple Myeloma
  • Cancer
  • PSCT
  • Peripheral Stem Cell Transplant
  • Chemotherapy
  • GVAX
03

In context

Multiple Myeloma

3,632 studies on the registry are indexed under Multiple Myeloma; 745 are open to participants now.

This study's enrollment of 22 is below the median of 41 across 2,907 interventional studies indexed under Multiple Myeloma.

Browse Multiple Myeloma studies →

Lead sponsor

Cell Genesys is the lead sponsor of 12 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • De novo multiple myeloma
  • ECOG 0-2
  • No serious co-morbid illnesses and adequate organ function
  • > 4 weeks from systemic steroids

Exclusion criteria

Exclusion Criteria:

  • No existing secondary malignancies and no history of secondary malignancies in the past 5 years
  • No active autoimmune disease
05

Study design

Phase
Phase 1 / Phase 2
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
22 participants

Interventions

  • BiologicalTherapeutic Cellular Vaccine, GM-CSF Producing
06

What researchers measure

Primary outcomes

  1. Multiple myeloma

07

Study locations

1 site
  • Johns Hopkins University
    Baltimore, Maryland 21231, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 24, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00116441
Lead sponsor
Cell Genesys
First posted
Jun 30, 2005
Start date
Oct 2000
Completion
Oct 2004
Last update
Dec 24, 2007
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2007. You cannot join it, but the record below documents what was studied.

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