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CompletedNCT00114725Updated Jun 24, 2005

Laser-Assisted Versus Conventional Intracytoplasmic Sperm Injection

An interventional study of Laser-assisted intracytoplasmic sperm injection in Infertility and Infertility, Male, sponsored by Shady Grove Fertility Reproductive Science Center. Completed at 1 site in United States. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2005-06-24.

Sponsored by Shady Grove Fertility Reproductive Science Center · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

Laser-assisted intracytoplasmic sperm injection (ICSI) has been suggested as a more effective alterative to conventional ICSI when this method of insemination is indicated for patients undergoing in vitro fertilization (IVF). Laser-assisted ICSI differs from conventional ICSI in that a laser is used to drill a small hole through the hard outer coating surrounding an egg before the injection needle containing a single sperm is inserted into the egg. The hole eliminates compression of the egg that normally occurs with conventional ICSI, and thus may reduce the chance of damage. Laser-assisted ICSI is hypothesized to result in increased egg survival, and perhaps improved embryo quality, compared to conventional ICSI.

02

Conditions studied

  • Infertility
  • Infertility, Male

Keywords

  • In Vitro Fertilization
  • Intracytoplasmic Sperm Injection
  • Oocytes
  • Zona Pellucida
  • Oolemma
  • Fertilization
  • Preimplantation Embryo Development
03

In context

Infertility

2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.

This study's enrollment of 60 is below the median of 120 across 1,698 interventional studies indexed under Infertility.

Browse Infertility studies →

Lead sponsor

Shady Grove Fertility Reproductive Science Center is the lead sponsor of 10 studies on the registry; 5 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Diagnosis of infertility
  • Scheduled for IVF with ICSI

Exclusion criteria

Exclusion Criteria:

  • Retrieval of fewer than 6 mature oocytes
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Factorial assignment
Masking
None (open label)
Enrollment
60 participants

Interventions

  • ProcedureLaser-assisted intracytoplasmic sperm injection
06

What researchers measure

Primary outcomes

  1. oocyte survival rate 1 day after ICSI

Secondary outcomes

  1. normal fertilization rate 1 day after ICSI

  2. embryo cell numbers 2 and 3 days after ICSI

  3. embryo fragmentation rates 2 and 3 days after ICSI

  4. embryo compaction rate through day 7 after ICSI

  5. blastocyst formation rate through day 7 after ICSI

07

Study locations

1 site
  • Shady Grove Fertility Reproductive Science Center
    Rockville, Maryland 20850, United States
08

References and documents

Publications

  • Mikhailusov SV, Bart BIa, Siluianov SV, Mikhailusova MP, Nikolaeva AS. [Duodenogastric reflux and gastric pathology in the elderly patients]. Eksp Klin Gastroenterol. 2010;(12):54-9. Russian. PubMed 21560622 ↗
  • Kurashige H, Cateau H. Dendritic slow dynamics enables localized cortical activity to switch between mobile and immobile modes with noisy background input. PLoS One. 2011;6(9):e24007. doi: 10.1371/journal.pone.0024007. Epub 2011 Sep 8. PubMed 21931635 ↗
  • Chand AL, Wijayakumara DD, Knower KC, Herridge KA, Howard TL, Lazarus KA, Clyne CD. The orphan nuclear receptor LRH-1 and ERalpha activate GREB1 expression to induce breast cancer cell proliferation. PLoS One. 2012;7(2):e31593. doi: 10.1371/journal.pone.0031593. Epub 2012 Feb 16. PubMed 22359603 ↗
  • Semiglazov VF, Paltuev RM, Remizov AS, Semiglazov VV, Dashian GA, Bessonov AA, Pen'kov KD, Vasil'ev AG, Semiglazova TIu, Kolar'kova VV. [The role of nanotechnology in creating novel antitumor agents]. Vopr Onkol. 2011;57(5):636-40. Russian. PubMed 22238935 ↗
  • Rienzi L, Ubaldi F, Martinez F, Minasi MG, Iacobelli M, Ferrero S, Tesarik J, Greco E. Clinical application of laser-assisted ICSI: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2004 Jul 1;115 Suppl 1:S77-9. doi: 10.1016/j.ejogrb.2004.01.017. PubMed 15196721 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 24, 2005, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00114725
Lead sponsor
Shady Grove Fertility Reproductive Science Center
First posted
Jun 17, 2005
Start date
Mar 2004
Completion
Oct 2004
Last update
Jun 24, 2005

Study contacts

Alana Davis, BS
principal investigator · Shady Grove Fertility Reproductive Science Center
Kevin S Richter, PhD
study director · Shady Grove Fertility Reproductive Science Center
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jun 2005. You cannot join it, but the record below documents what was studied.

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