CClinicalTrials.gg
TerminatedNCT00104130Updated Sep 17, 2008

Study of KOS-862 (Epothilone D) in Metastatic Prostate Cancer

A Phase 2 interventional study of KOS-862 in Prostate Cancer, sponsored by Bristol-Myers Squibb. Terminated at 9 sites in United States. Open to male participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2008-09-17.

Sponsored by Bristol-Myers Squibb · Phase 2, Interventional, and Treatment

Phase
Phase 2
Study type
Interventional
Enrollment
53
Allocation
Non-randomized
Ages
18 Years and older
Sex
Male
01

Study summary

The purpose of this trial is to study KOS-862 in men with metastatic prostate cancer who have failed a docetaxel-containing regimen.

Read the detailed description

This study is a Phase 2, single arm study of KOS-862 in men with metastatic prostate cancer who have failed a docetaxel-containing regimen. PSA response is the primary end-point and objective responses will be checked as available.

02

Conditions studied

  • Prostate Cancer

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Keywords

  • prostate
03

In context

Prostatic Neoplasms

6,367 studies on the registry are indexed under Prostatic Neoplasms; 1,397 are open to participants now.

This study's enrollment of 53 is close to the median of 58 across 4,821 interventional studies indexed under Prostatic Neoplasms.

Browse Prostatic Neoplasms studies →

Lead sponsor

Bristol-Myers Squibb is the lead sponsor of 1,538 studies on the registry; 116 are open to participants now.

Of its 429 completed or terminated interventional studies of FDA-regulated products, 223 (52%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
Male
Accepts healthy volunteers
No

Inclusion criteria

  • At least 18 years of age.
  • Metastatic disease.
  • One previous treatment including docetaxel (Taxotere).
  • At least 3 weeks since last surgery/radiation/chemotherapy
  • ECOG Performance Status of 0, 1 or 2

Exclusion criteria

Exclusion Criteria:

  • Active brain metastases
05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
53 participants

Interventions

  • DrugKOS-862
06

What researchers measure

Primary outcomes

  1. prostate cancer

  2. prostate-specific antigen (PSA) response

07

Study locations

9 sites
  • Kaiser Permanente Medical Center
    Vallejo, California 94589, United States
  • Georgia Cancer Specialists
    Tucker, Georgia 30084, United States
  • University of Maryland Medical System
    Baltimore, Maryland 21201, United States
  • Washington University School of Medicine
    St. Louis, Missouri 63310, United States
  • The Cleveland Clinic Foundation
    Cleveland, Ohio 44195, United States
  • Kaiser Permanente NW Oncology Clinic
    Portland, Oregon 97227, United States
  • Oregon Health & Science University
    Portland, Oregon 97239, United States
  • Fox Chase Cancer Center
    Philadelphia, Pennsylvania 19111, United States
  • University of Washington
    Seattle, Washington 98109, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 17, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00104130
Lead sponsor
Bristol-Myers Squibb
First posted
Feb 24, 2005
Start date
Dec 2004
Completion
Feb 2005
Last update
Sep 17, 2008
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Sep 2008. You cannot join it, but the record below documents what was studied.

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