A Phase 4 interventional study of levodopa and rivastigmine in Healthy, sponsored by University Hospital Muenster. Terminated at 1 site in Germany. Open to participants aged 20 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-01-27.
Sponsored by University Hospital Muenster · Phase 4, Interventional, and Treatment
The purpose of this study is to determine whether levodopa, pergolid, rivastigmine, or modafinil are effective in boosting semantic language acquisition in healthy subjects.
Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether a mixed d1/d2 dopamine agonist (pergolid) or cholinergic neuromodulation (rivastigmine) or a general centrally arousing substance (modafinil) will yield a learning enhancement comparable to using levodopa in healthy subjects.
Our results show that the dopamine agonist pergolide impaired learning in healthy subjects compared to placebo, whereas cholinergic neuromodulation had no effect.
University Hospital Muenster is the lead sponsor of 189 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Boost in language learning success through neuromodulation
Stability of language learning success
This study is terminated, as verified in Sep 2006. You cannot join it, but the record below documents what was studied.
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University Hospital Muenster