Carboplatin and Paclitaxel With or Without Bevacizumab Compared to Docetaxel, Carboplatin, and Paclitaxel in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Carcinoma (Cancer)

Inclusion Criteria:

• Histologically confirmed fallopian tube, ovarian epithelial, or primary peritoneal carcinoma

  • Stage II-IV disease

  • The following epithelial cell types are allowed:

    • Carcinosarcoma
    • Serous adenocarcinoma
    • Endometrioid adenocarcinoma
    • Mucinous adenocarcinoma
    • Undifferentiated carcinoma
    • Clear cell adenocarcinoma
    • Mixed epithelial carcinoma
    • Transitional cell carcinoma
    • Malignant Brenner's tumor
    • Adenocarcinoma not otherwise specified

• Must have undergone prior surgery for ovarian or peritoneal carcinoma within the past 12 weeks

  • Optimal (≤ 1 cm residual disease) or suboptimal residual disease following initial surgery
  • Must have a procedure for determining diagnosis of ovarian/peritoneal carcinoma with appropriate tissue for histologic evaluation

• Synchronous primary endometrial cancer or prior endometrial cancer allowed provided the following criteria are met:

  • Stage ≤ IB
  • Less than 3 mm invasion without vascular or lymphatic invasion
  • No poorly differentiated subtypes (e.g., grade 3, clear cell, or papillary serous)
• No epithelial ovarian carcinoma of low malignant potential (borderline carcinomas)
• No CNS disease (e.g., seizures not controlled with standard medical therapy) or metastasis
• GOG performance status 0-2
• Absolute neutrophil count ≥ 1,500/mm\^3
• Platelet count ≥ 100,000/mm\^3
• INR ≤ 1.5 (or an in-range INR, usually between 2 and 3, if a patient is on a stable dose of therapeutic warfarin for management of venous thrombosis including pulmonary thrombo-embolus) (applies to part C only)
• PTT \< 1.2 times the upper limit of normal (applies to part C only)
• SGOT ≤ 2.5 times normal
• Alkaline phosphatase ≤ 2.5 times normal
• Bilirubin ≤ 1.5 times normal
• Creatinine ≤ 1.5 times normal
• No active bleeding
• Abnormal cardiac conduction (e.g., bundle branch block or heart block) allowed provided disease has remained stable for the past 6 months
• No unstable angina or myocardial infarction within the past 6 months
• No neuropathy (sensory and motor) > CTCAE grade 1
• Not pregnant or nursing
• Fertile patients must use effective contraception during and for at least 6 months after completion of study therapy
• No septicemia, severe infection, or acute hepatitis
• No other invasive malignancy within the past 5 years except non-melanoma skin cancer or localized breast cancer
• No circumstance that would preclude study participation
• No history of allergic reaction to polysorbate 80 (e.g., etoposide or vitamin E)
• No known hypersensitivity to Chinese hamster ovary cell products or other recombinant human or humanized antibodies (applies to part C only)

• No clinically significant proteinuria

  • Must have urine protein-creatinine ratio (UPCR) \< 1
• No serious, non-healing wound, ulcer, or bone fracture (applies to part C only)
• At least 3-6 months since prior abdominal fistula or gastrointestinal perforation and fully recovered (part C only)
• No history of intra-abdominal abscess within the past 28 days (applies to part C only)
• No active bleeding or pathologic conditions that carry high risk of bleeding, such as known bleeding disorder, coagulopathy, or tumor involving major vessels (applies to part C only)
• No history or evidence (upon physical examination) of CNS disease, including primary brain tumor, seizures not controlled with standard medical therapy, or brain metastases (applies to part C only)
• No history of cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA) or subarachnoid hemorrhage within six months of the first date of treatment on this study (applies to part C only)
• No significant traumatic injury within 28 days (applies to part C only)

• No clinically significant cardiovascular disease, including any of the following (applies to part C only):

  • Uncontrolled hypertension, defined as systolic BP > 150 mm Hg or diastolic BP > 90 mm Hg
  • Myocardial infarction or unstable angina \< 6 months prior to registration
  • New York Heart Association (NYHA) Grade II or greater congestive heart failure
  • Serious cardiac arrhythmia requiring medication
  • CTCAE Grade 2 or greater peripheral vascular disease (at least brief (\< 24 hrs) episodes of ischemia managed non-surgically and without permanent deficit)
  • History of CVA within the past six months
• No clinical symptoms or signs of gastrointestinal obstruction and who require parenteral hydration and/or nutrition (applies to part C only)
• No prior therapy with any anti-VEGF drug, including bevacizumab (applies to part C only)

• No prior chemotherapy

  • Prior adjuvant chemotherapy for localized breast cancer allowed provided the therapy was completed at least 3 years before registration to study and the patient remains free of recurrent or metastatic disease
• No prior radiotherapy
• No prior cancer therapy that would contraindicate study treatment

• No anticipation of invasive procedures, including any of the following (applies to part C only):

  • Major surgical procedure or open biopsy within 28 days prior to the first date of bevacizumab therapy (cycle 2)
  • Major surgical procedure anticipated during the course of the study
  • Core biopsy within 7 days prior to the first date of bevacizumab therapy