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CompletedNCT00073515Updated Feb 3, 2010

Trial of a Novel Fibrinolytic (Alfimeprase) to Clear Thrombosed Vascular Access Devices

A Phase 2 interventional study of Alfimeprase in Catheters, Indwelling, sponsored by ARCA Biopharma, Inc.. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2010-02-03.

Sponsored by ARCA Biopharma, Inc. · Phase 2, Interventional, and Treatment

Phase
Phase 2
Study type
Interventional
Enrollment
115
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

This trial is for patients with a central venous catheter (a vascular access device) that is not functioning properly (unable to withdraw blood). The trial compares a new blood clot dissolving agent (alfimeprase) against the currently used treatment.

02

Conditions studied

  • Catheters, Indwelling

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Keywords

  • central venous access device
  • thrombosis
  • central venous catheter
  • thrombolysis
  • fibrinolysis
03

In context

Thrombosis

1,528 studies on the registry are indexed under Thrombosis; 240 are open to participants now.

This study's enrollment of 115 is close to the median of 107 across 866 interventional studies indexed under Thrombosis.

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Lead sponsor

ARCA Biopharma, Inc. is the lead sponsor of 12 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Subjects must:

  • have a dysfunctional Central Venous Access Device (CVAD) defined as unable to withdraw 3 mL blood
  • have had the device in place for > 48 hours
  • be clinically stable
  • be 18 or older
  • give informed consent
05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Single group
Masking
Double
Enrollment
115 participants

Interventions

06

Study locations

1 site
  • Cleveland Clinic Foundation
    Cleveland, Ohio, United States
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 3, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT00073515
Lead sponsor
ARCA Biopharma, Inc.
First posted
Nov 25, 2003
Last update
Feb 3, 2010
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2005. You cannot join it, but the record below documents what was studied.

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Discussion

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Studies of the drug tested here: Alfimeprase

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