CClinicalTrials.gg
CompletedNCT00072917Updated Jan 18, 2010

The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women

An observational study in Obesity, Thinness and Weight Gain, sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Completed at 1 site in United States. Open to participants aged 25 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-01-18.

Sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
100
Ages
25 Years to 35 Years
Sex
All
01

Study summary

This is a longitudinal cohort study of how the responses to a 3 day period of controlled overfeeding relate to subsequent weight gain. We hypothesize that thin individuals are resistant to weight gain because they respond to periods of overfeeding by increasing fat oxidation, reducing food intake, and increasing physical activity relative to those who gain weight over time.

02

Conditions studied

  • Obesity
  • Thinness
  • Weight Gain

Keywords

  • obesity
  • thinness
  • weight gain
  • physical activity
  • diet
  • fat oxidation
  • hunger
  • feeding behavior
  • overfeeding
03

In context

Obesity

6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.

This study's planned enrollment of 100 is below the median of 135 across 1,283 observational studies indexed under Obesity.

Browse Obesity studies →

Lead sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is the lead sponsor of 529 studies on the registry; 54 are open to participants now.

Of its 79 completed or terminated interventional studies of FDA-regulated products, 50 (63%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
25 Years to 35 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Subjects have been recruited through advertisements in local news media and on the internet

Eligibility criteria

  • Half of the subjects will be women, half will be men,
  • age 25-35,
  • a range of BMI's from 19-27, for the 'thin subjects' there should be no 1st degree relatives with a BMI>30.
  • Subjects should not engage in planned physical activity more than 3 hrs per week.
  • For the obesity prone group there should be at least 1 1st degree relative with a BMI>30.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
100 participants (estimated)
Biospecimen retention
Samples with dna
06

Study locations

1 site
  • University of Colorado Health Sciences Center
    Denver, Colorado 80262, United States
07

References and documents

Publications

  • Rynders CA, Pereira RI, Bergouignan A, Kealey EH, Bessesen DH. Associations Among Dietary Fat Oxidation Responses to Overfeeding and Weight Gain in Obesity-Prone and Resistant Adults. Obesity (Silver Spring). 2018 Nov;26(11):1758-1766. doi: 10.1002/oby.22321. PubMed 30358145 ↗
  • Creasy SA, Rynders CA, Bergouignan A, Kealey EH, Bessesen DH. Free-Living Responses in Energy Balance to Short-Term Overfeeding in Adults Differing in Propensity for Obesity. Obesity (Silver Spring). 2018 Apr;26(4):696-702. doi: 10.1002/oby.22121. PubMed 29570248 ↗
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 18, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00072917
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
First posted
Nov 14, 2003
Start date
Oct 2003
Completion
Jun 2008
Last update
Jan 18, 2010

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2010. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion