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TerminatedNCT00057447Updated Nov 1, 2007

Safety of Interferon Gamma-1b With Rituximab in Non-Hodgkin's Lymphoma Patients

A Phase 1/2 interventional study of Interferon Gamma-1b and Rituximab in Non-Hodgkin's Lymphoma, sponsored by InterMune. Terminated at 1 site in United States. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2007-11-01.

Sponsored by InterMune · Phase 1/2, Interventional, and Treatment

Why this study was terminated
administrative reasons
Phase
Phase 1/2
Study type
Interventional
Enrollment
24
Allocation
Non-randomized
Ages
18 Years to 80 Years
Sex
All
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Study summary

Evaluate the safety and efficacy of the dosing schedule of subcutaneous interferon gamma-1b (IFN g-1b) administered 3 times per week with Rituximab for 4 weeks, in patients with progressive or relapsed low-grade Non-Hodgkin's Lymphoma (NHL)

International study with sites in the Czech Republic and Poland

02

Conditions studied

  • Non-Hodgkin's Lymphoma

Keywords

  • lymphoma
03

In context

Lymphoma

5,578 studies on the registry are indexed under Lymphoma; 825 are open to participants now.

This study's enrollment of 24 is below the median of 40 across 4,508 interventional studies indexed under Lymphoma.

Browse Lymphoma studies →

Lead sponsor

InterMune is the lead sponsor of 15 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

  • Relapsed or progressive low-grade/follicular NHL who are candidates for rituximab therapy
  • Patients who were on other therapy including CHOP or radiation
  • Previous therapy must have concluded 30 days prior to enrollment
  • Demonstrable CD20-positive tumor population in lymph nodes or bone marrow
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Study design

Phase
Phase 1 / Phase 2
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
24 participants (actual)

Interventions

  • DrugInterferon Gamma-1b

    100 or 200 mcg, SQ, 3x per week

  • DrugRituximab

    375 mg per square meters, IV, 1x per week

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What researchers measure

Primary outcomes

  1. time to complete response (disappearance of all detectable clinical and radiographic evidenc of disease, and regression of lymph nodes)

    Time frame: 6 weeks

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Study locations

1 site
  • Intermune Inc
    Brisbane, California 94005, United States
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 1, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00057447
Lead sponsor
InterMune
First posted
Apr 3, 2003
Start date
Mar 2003
Completion
Jun 2004
Last update
Nov 1, 2007

Study contacts

Williamson Bradford, MD
study director · InterMune
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Oct 2007. You cannot join it, but the record below documents what was studied.

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