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CompletedNCT00018668Updated Jan 21, 2009

Antipsychotic Response in Schizophrenia

A Phase 4 interventional study of Risperidone and Olanzapine in Schizophrenia, sponsored by US Department of Veterans Affairs. Completed at 1 site in United States. Open to participants aged 21 Years to 70 Years. Per ClinicalTrials.gov, last updated 2009-01-21.

Sponsored by US Department of Veterans Affairs · Phase 4, Interventional, and Treatment

Phase
Phase 4
Study type
Interventional
Allocation
Randomized
Ages
21 Years to 70 Years
Sex
All
01

Study summary

Motor slowing is a hallmark, clinical sign in mental illness. Slowness can be related to a specific disease process, as in negative schizophrenia or depression or it can be the result of medications used to treat forms of mental illness. Prior research has lead to a novel instrumental approach for distinguishing subtypes of motor slowing - one type related to cognitive processes and another related to parkinsonism. The purpose of this study is to test whether new medications used to treat schizophrenia improve the cognitive or parkinsonian components of motor slowing. Patients will be studied in the laboratory before and 8-weeks after starting a new antipsychotic. The n of this study = 60 patients. The results of this study will improve our understanding of the complex interactions between cognitive processing and motor behavior in patients with psychotic illnesses and how drugs work to treat these problems.

02

Conditions studied

  • Schizophrenia

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Keywords

  • Antipsychotics
  • schizophrenia
  • motor retardation
  • bradykinesia
03

In context

Schizophrenia

3,471 studies on the registry are indexed under Schizophrenia; 472 are open to participants now.

Browse Schizophrenia studies →

Lead sponsor

US Department of Veterans Affairs is the lead sponsor of 658 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
21 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Schizophrenia diagnosis currently treated with conventional antipsychotic willing to be switched to an atypical antipsychotic.

05

Study design

Phase
Phase 4
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)

Interventions

  • DrugRisperidone
  • DrugOlanzapine
  • DrugQuetiapine
06

Study locations

1 site
  • Department of Veterans Affairs
    San Diego, California 92161, United States
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 21, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT00018668
Lead sponsor
US Department of Veterans Affairs
First posted
Jul 5, 2001
Start date
Oct 2000
Completion
Sep 2004
Last update
Jan 21, 2009
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Dec 2004. You cannot join it, but the record below documents what was studied.

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