An observational study in Central Nervous System Embryonal Neoplasm, sponsored by Pediatric Brain Tumor Consortium. Completed at 9 sites in United States. Open to participants aged Up to 2 Years. Per ClinicalTrials.gov, last updated 2011-07-20.
Sponsored by Pediatric Brain Tumor Consortium · Observational
RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer.
PURPOSE: Genetic study to learn more about genes involved in the development of central nervous system tumors in young children.
OBJECTIVES:
OUTLINE: This is a multicenter study.
Tumor samples are analyzed using microarray gene chip analysis. Differentially expressed genes are evaluated for protein expression by standard immunohistochemistry and/or Western blot analysis, and gene expression is further quantified by semi-quantitative polymerase chain reaction.
PROJECTED ACCRUAL: Approximately 80-100 patients (20-25 with metastatic disease and 60-75 with non-metastatic disease) will be accrued for this study within 4-5 years.
538 studies on the registry are indexed under Nervous System Neoplasms; 14 are open to participants now.
This study's enrollment of 83 is close to the median of 87 across 50 observational studies indexed under Nervous System Neoplasms.
Browse Nervous System Neoplasms studies →Pediatric Brain Tumor Consortium is the lead sponsor of 31 studies on the registry; none are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 4 (80%) have results posted.
Counted across the registry records on this site, refreshed daily.
The participants in this study are infants (\< 3 years of age) with newly diagnosed medulloblastoma, primitive neuroectodermal tumor, or other embryonal tumor, atypical teratoid/rhabdoid tumor, intracranial germ cell tumor, or choroid plexus carcinoma who have received no prior therapy with the exception of steroids and have consented to allow research studies on banked tissue specimens
DISEASE CHARACTERISTICS:
Histologically confirmed, newly diagnosed, primary intracranial embryonal central nervous system tumor
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy:
Surgery:
Other:
The participants in this study are infants (\< 3 years of age) with newly diagnosed medulloblastoma, primitive neuroectodermal tumor, or other embryonal tumor, atypical teratoid/rhabdoid tumor, intracranial germ cell tumor, or choroid plexus carcinoma who have received no prior therapy with the exception of steroids and have consented to allow research studies on banked tissue specimens
Genes that are expressed in metastatic vs. non-metastatic tumors
Time frame: Prior to therapy
Protein expression of genes found to be expressed
Time frame: Prior to therapy
This study is completed, as verified in Jul 2011. You cannot join it, but the record below documents what was studied.
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Pediatric Brain Tumor Consortium