An observational study in Dermatologic Diseases and Systemic Diseases With Cutaneous Manifestations, sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). Completed at 1 site in United States. Open to participants aged 1 Day to 120 Years. Per ClinicalTrials.gov, last updated 2025-04-13.
Sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · Observational
This is a training, natural history of disease, and screening protocol for the evaluation, treatment and follow-up of patients with dermatologic diseases and systemic diseases with cutaneous manifestations. Patients enrolled in this protocol will be evaluated and treated according to generally available, standard procedures and therapeutic modalities. Samples of blood and skin will be studied by routine and specialized investigative methods to establish these patients' diagnosis, response to treatment, and/or disease progression.
Background
This is a training, natural history of disease, and screening protocol for the evaluation, treatment and follow-up of patients with dermatologic diseases and systemic diseases with cutaneous manifestations. This protocol was developed to allow subject enrollment for teaching purposes and to allow for second opinions regarding relatively complicated patients, and to allow for evaluation of non-invasive tools for the diagnosis and monitoring of cutaneous manifestations. This protocol promotes a critical link between the NCI, CCR Dermatology Branch and the local and national extramural medical communities.
Objectives:
Eligibility:
All subjects regardless of age, gender, or racial/ethnic group with dermatologic disease or systemic disease with cutaneous manifestations.
Design:
Patients enrolled in this protocol will be evaluated and treated according to generally available, standard procedures and therapeutic modalities. Samples of blood and skin will be studied by routine and specialized investigative methods to establish these patients diagnosis, response to treatment, and/or disease progression. Non-invasive tools may be used as part of the examination and assessment of cutaneous manifestations of disease.
538 studies on the registry are indexed under Skin Diseases; 92 are open to participants now.
This study's enrollment of 453 is above the median of 168 across 147 observational studies indexed under Skin Diseases.
Browse Skin Diseases studies →National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is the lead sponsor of 100 studies on the registry; 12 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 5 (71%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients with dermatologic diseases and systemic diseases with cutaneous manifestations
Patients of any age (only viable neonates will enroll in the study), of both genders, and all racial/ethnic groups with dermatologic diseases or systemic diseases with cutaneous manifestations that will help the Branch fulfill the objectives.
Women who are pregnant or lactating, will only undergo tests and procedures, and/or receive medications for which data exists proving minimal risk to the fetus and/or child.
Patients must have a referring physician who will continue to assume primary medical responsibility of care for the patient during and after enrollment in this protocol.
EXCLUSION CRITERIA:
Any participant who, in the investigator s opinion, would be unable to comply with study requirements or for whom participation may pose a greater medical risk.
With dermatologic diseases and systemic diseases with cutaneous manifestations
Provide clinical material
Provide clinical material
Time frame: Ongoing
Natural history of selected dermatologic diseases
Natural history of selected dermatologic diseases
Time frame: Ongoing
Plan to share: Undecided — Protocol is silent on individual participant data (IPD) sharing plan.
This study is completed, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)