Yale University: Depressive Disorder, Major trials

The registry lists 17 Depressive Disorder, Major studies with Yale University as lead sponsor. 4 are open to participants now and 4 have results posted.

Phase 1 4Phase 2 3Phase 3 1Phase 4 1No phase 9(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• REWIRE: Real-world Engagement With Interventional and Rejoyn EffectivenessNot yet recruitingNCT07792252
• Imaging Depression in Parkinson's DiseaseRecruitingNCT06402955Phase 2
• Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine ResponseRecruitingNCT05915013Phase 1
• The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal EffectsRecruitingNCT05786066Phase 2
• Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily RhythmsCompletedNCT05317481Not applicableResults posted
• Ketamine for Severe Adolescent Depression: Intermediate-term Safety and EfficacyTerminatedNCT03889756Phase 2/3Results posted
• Ketamine Infusion for Adolescent Depression and AnxietyCompletedNCT02579928Phase 4Results posted
• PET Imaging of mGLuR5 With Drug ChallengeCompletedNCT01691092Not applicableResults posted
• Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic PsychedelicsTerminatedNCT06624137
• Fixed Order, Open-Label, Dose-Escalation Study of DMT in HumansActive, not recruitingNCT04711915Phase 1
• Imaging mGluR5 and Synaptic Density in Psychiatric DisordersCompletedNCT03898297
• Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive DisorderActive, not recruitingNCT03554174Phase 1
• Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot TrialCompletedNCT03367533Phase 1
• Cognitive Therapy to Sustain the Antidepressant Effects of Intravenous Ketamine in Treatment-resistant DepressionCompletedNCT03027362Not applicable
• Imaging SV2A in Mood DisordersActive, not recruitingNCT02734602Not applicable
• Examination of Glutamate and mGluR5 in Psychiatric DisordersCompletedNCT02727972
• Duloxetine for the Treatment of Postpartum DepressionWithdrawnNCT00617045Not applicable