University of North Carolina, Chapel Hill: Depression trials

The registry lists 48 Depression studies with University of North Carolina, Chapel Hill as lead sponsor. 10 are open to participants now and 21 have results posted.

Phase 1 1Phase 2 5Phase 3 2Phase 4 5No phase 37(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Single Session Personalized Aperiodic Transcranial Alternating Current Stimulation (PandA-tACS) for Antenatal DepressionNot yet recruitingNCT07799480Not applicable
• CARED : A Novel Rapid Treatment Paradigm for DepressionRecruitingNCT07507370Not applicable
• Enhanced Problem-solving Therapy and HIV Engagement Support to Improve Perinatal Mental Health & HIV Outcomes in MalawiRecruitingNCT06702722Not applicable
• Neuroscience of Psychotherapy for DepressionRecruitingNCT06696001Not applicable
• Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of DepressionRecruitingNCT06610305Phase 4
• Teachers Leading the Front Lines - North Carolina (Tealeaf-NC)RecruitingNCT06587230Not applicable
• Aligning Facility Leadership and Climate to Advance Mental Health Services Integration in MalawiRecruitingNCT06399991Not applicable
• Teachers Leading the Front Lines - AdolescentRecruitingNCT06248203Not applicable
• Adolescent Mood During Puberty and TestosteroneRecruitingNCT06072677Not applicable
• Examining the Effects of Estradiol on Neural and Molecular Response to RewardRecruitingNCT05282277Phase 4
• Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)TerminatedNCT06979154Not applicableResults posted
• Effects of SinuSonic on Psychological and Physical Well-BeingTerminatedNCT06268730Not applicableResults posted
• HIV Engagement and Adolescent Depression Support (HEADS-UP)CompletedNCT06173544Not applicableResults posted
• Dynamic Neural Mechanisms of Brexanolone-induced Antidepressant Effects in Postpartum DepressionCompletedNCT05543746Results posted
• iTBS for Adolescent Depression: An Open Label Study Evaluating Safety and Efficacy of TreatmentCompletedNCT04485455Not applicableResults posted
• Adaptation of the Friendship Bench Intervention for HIV-infected Perinatal Women in LilongweCompletedNCT04143009Not applicableResults posted
• LUPUS Brain: tACS to Target the Neurophysiology of Depression, Cognitive Deficits, and Pain in Patients With SLETerminatedNCT04141046Not applicableResults posted
• A Pilot Trial of Perinatal Depression Treatment in HIV Infected WomenCompletedNCT04094870Phase 4Results posted
• Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine ModelCompletedNCT04051320Phase 2Results posted
• Mechanism of Action of tACS for the Treatment of MDDCompletedNCT03994081Not applicableResults posted
• Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause"CompletedNCT03740009Phase 4Results posted
• The Sub-Saharan Africa Regional Partnership for Mental Health Capacity BuildingCompletedNCT03711786Not applicableResults posted
• Using the LENA System in Early Intervention - bCompletedNCT03480841Not applicableResults posted
• Single Session of tACS in a Depressive EpisodeCompletedNCT03449979Not applicableResults posted
• The S.M.A.R.T. Project: Stress Management and Resilience Training for TeensCompletedNCT03270943Not applicableResults posted
• Transcranial Alternating Current Stimulation for Major Depressive DisorderCompletedNCT02339285Not applicableResults posted
• Perimenopausal Effects of Estradiol on Reward ResponsivenessCompletedNCT02255175Phase 4Results posted
• Neurophysiology of Postpartum Depression in an Experimental Model of Pregnancy and ParturitionCompletedNCT01762943Not applicableResults posted
• Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and AdolescentsCompletedNCT01731119Phase 2Results posted
• Perimenopausal Estrogen Replacement Therapy StudyCompletedNCT01308814Phase 2/3Results posted
• Second-Generation Antipsychotic Treatment Indication Effectiveness And Tolerability In Youth (Satiety) StudyCompletedNCT01269710Results posted
• Psychotherapy Feasibility Pilot of the Carolina Recovery From Depression ProtocolCompletedNCT06590038Not applicable
• Psilocybin-Assisted Therapy in Treatment-Resistant DepressionActive, not recruitingNCT06303739Phase 3
• Self-Compassion to Enhance the Well-Being of Caregivers of Children With Physical DisabilitiesCompletedNCT06271824Not applicable
• Mitigating Mental Health Issues Among Women's Sport Student-Athletes Through a Moderate-Intensity Exercise InterventionCompletedNCT06182150Not applicable
• Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic AdultsActive, not recruitingNCT06060860Not applicable
• Depression, Aging, Stress and Heart Health StudyCompletedNCT05570721Not applicable
• Project SOAR-Mental Health Malawi: Depression and HIV IntegrationCompletedNCT03555669Not applicable
• Using the LENA System in Early InterventionWithdrawnNCT03164642Not applicable
• Depression Amongst HIV Positive Patients in LilongweCompletedNCT02646605
• CID 0911 - Adaptation of A Depression Treatment Intervention for HIV Patients in CameroonCompletedNCT02156622
• Determining Relationships Among Maternity Stress & SleepCompletedNCT02133963
• Study of Exposure to Stress, Postpartum Mood, Adverse Life Events, and Hormonal Function Among Latinas (SEPAH Latina)CompletedNCT01912833
• Partner-Assisted Interpersonal Psychotherapy or Antidepressant Medication for Antenatal DepressionTerminatedNCT01732055Phase 1/2
• Behavioral Depression Treatment for African American HIV-infected Substance UsersCompletedNCT01351454Not applicable
• Treatment for Depression Among HIV-Infected YouthCompletedNCT01049789Not applicable
• Brain Imaging of Psychotherapy for DepressionCompletedNCT00609453Not applicable
• Reducing Symptoms of Depression in Low-Income MothersCompletedNCT00074789Phase 2