University of Cape Town: Tuberculosis trials

The registry lists 26 Tuberculosis studies with University of Cape Town as lead sponsor. 3 are open to participants now and 1 have results posted.

Phase 1 1Phase 2 5Phase 3 6Phase 4 2No phase 15(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Same Day Diagnosis of Extrapulmonary TB (TB Serositis and TB Meningitis).RecruitingNCT06135818Not applicable
• Gene Expression Profiles in Spinal Tuberculosis.RecruitingNCT05610098
• Atorvastatin to Reduce Inflammation After Tuberculosis Treatment CompletionRecruitingNCT04147286Phase 2/3
• Standard Versus Double Dose Dolutegravir in Patients With HIV-associated TuberculosisCompletedNCT03851588Phase 2Results posted
• Evaluating the Impact of Computer-assisted X-ray Diagnosis and Other Triage Tools to Optimise Xpert Orientated Community-based Active Case Finding for TB and COVID-19Active, not recruitingNCT05220163Not applicable
• Xpert Active Case-finding Trial 3 (XACT-3)CompletedNCT04303104Not applicable
• Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBMCompletedNCT03927313Phase 2
• Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis-PandrTB TuberculosisStatus unknownNCT03827811
• Xpert Active Case-finding Trial 2: Community-based Active Case-finding for Tuberculosis in South AfricaCompletedNCT03168945Not applicable
• The Bioavailability of Rifampicin in (FDCs) Widely Used in South Africa to Treat Drug-susceptible (TB)CompletedNCT02953847Phase 1
• The Correlate of Risk Targeted Intervention StudyStatus unknownNCT02735590Phase 2/3
• Pharmacometric Optimization of Second Line Drugs for MDR Tuberculosis TreatmentCompletedNCT02727582
• An Open-label RCT to Evaluate a New Treatment Regimen for Patients With Multi-drug Resistant TuberculosisCompletedNCT02454205Phase 2/3
• The Utility of Intensified Case Finding Combined With a Package of Novel TB Diagnostics Using a Mobile Clinic in AfricaCompletedNCT01990274Not applicable
• Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of PrednisoneCompletedNCT01924286Phase 3
• A Trial of the Urine LAM Strip Test for TB Diagnosis Amongst Hospitalized HIV-infected PatientsCompletedNCT01770730Not applicable
• Optimal Dosing of 1st Line Antituberculosis and Antiretroviral Drugs in Children (a Pharmacokinetic Study)CompletedNCT01637558Phase 4
• Trial of Point-of-treatment Xpert MTB/RIF AssayCompletedNCT01554384Not applicable
• Utility of Sputum Induction and Novel Technologies to Improve TB Diagnosis in a High HIV Prevalence Primary Care SettingCompletedNCT01545661Not applicable
• Gene Xpert Diagnosis of TB Using Tracheal Aspirates From Intensive Care Unit (ICU) PatientsCompletedNCT01530568Not applicable
• A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous PericarditisCompletedNCT00810849Phase 3
• Rapid Diagnosis of Pulmonary TuberculosisStatus unknownNCT00608790Not applicable
• Isoniazid Plus Antiretroviral Therapy to Prevent Tuberculosis in HIV-infected PersonsCompletedNCT00463086Not applicable
• Isoniazid Prophylaxis With Concomitant Cotrimoxazole in HIV-infected ChildrenCompletedNCT00330304Phase 3
• Randomized Controlled Trial of Percutaneous and Intradermal BCG Vaccination.Status unknownNCT00242047Phase 4
• Effect of Public Sector Antiretroviral Treatment Programme on Tuberculosis and Immunization CareStatus unknownNCT00203762Not applicable