St. Jude Children's Research Hospital: Precursor Cell Lymphoblastic Leukemia-Lymphoma trials

The registry lists 72 Precursor Cell Lymphoblastic Leukemia-Lymphoma studies with St. Jude Children's Research Hospital as lead sponsor. 14 are open to participants now and 23 have results posted.

Phase 1 16Phase 2 25Phase 3 9Phase 4 2No phase 25(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Feasibility and Acceptability of Remote Saliva CollectionRecruitingNCT07884474
• CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and LymphomaRecruitingNCT07257419Phase 1
• Resistance Exercise and Incretin Mimetic for Cardiometabolic Health in Survivors of ALL With ObesityRecruitingNCT07228741Phase 2
• Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic LeukemiaRecruitingNCT07191119Not applicable
• Real World Asparaginase Therapy ToxicityNot yet recruitingNCT07008027
• CAR T CELL Therapy for Pediatric, Adolescent and Young Adult Patients With CD19-Positive LeukemiaRecruitingNCT06847269Phase 2
• Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia SurvivorsRecruitingNCT06819475Not applicable
• CD19-CD22-Bispecific Chimeric Antigen Receptor (CAR) T Cell Therapy for Pediatric Patients With Acute Lymphoblastic LeukemiaRecruitingNCT06777979Phase 1
• Assessment of Remote Approaches for Identification of Autonomic Dysfunction Among Survivors of Leukemia and LymphomaRecruitingNCT06747910Not applicable
• Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and LymphomaRecruitingNCT06533748Phase 2
• CAR T-cell Therapy Directed to CD70 for Pediatric Patients With Hematological MalignanciesRecruitingNCT06326463Phase 1
• Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/LymphomaRecruitingNCT06289673Phase 4
• Study of CD19 Allogeneic Memory T-cell Therapy for Relapsed/Refractory CD19+ LeukemiaRecruitingNCT04881240Phase 1
• Study of CM4620 to Reduce the Severity of Pancreatitis Due to AsparaginaseRecruitingNCT04195347Phase 1/2
• Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and NavitoclaxActive, not recruitingNCT05192889Phase 1/2Results posted
• Hypertension Intervention to Reduce Osteonecrosis in Children With Acute Lymphoblastic Leukemia/LymphomaCompletedNCT04401267Phase 2Results posted
• Neurostimulation In Adult Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)CompletedNCT04007601Not applicableResults posted
• TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic MalignanciesActive, not recruitingNCT03849651Phase 2Results posted
• Evaluation of CD19-Specific CAR Engineered Autologous T-Cells for Treatment of Relapsed/Refractory CD19+ Acute Lymphoblastic LeukemiaActive, not recruitingNCT03573700Phase 1/2Results posted
• Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) IActive, not recruitingNCT02553460Phase 1/2Results posted
• Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or LymphomaTerminatedNCT02518750Phase 2Results posted
• Bortezomib and Vorinostat in Younger Patients With Refractory or Relapsed MLL Rearranged Hematologic MalignanciesTerminatedNCT02419755Phase 2Results posted
• Treatment for Executive Dysfunction in Adult Survivors of Childhood Acute Lymphoblastic LeukemiaCompletedNCT02336282Not applicableResults posted
• Repeat Transplantation for Relapsed or Refractory Hematologic Malignancies Following Prior TransplantationTerminatedNCT02259348Phase 2Results posted
• Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and LymphomaCompletedNCT01700946Phase 2Results posted
• T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic TransplantTerminatedNCT01621477Phase 2Results posted
• Therapeutic Interventions For Pain Induced By Vincristine Treatment For Childhood Acute Lymphoblastic Leukemia (ALL)CompletedNCT01506453Phase 2Results posted
• NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic LymphomaCompletedNCT01451515Phase 2Results posted
• Methotrexate or Pentostatin for Graft-versus-host Disease Prophylaxis in Risk-adapted Allogeneic Bone Marrow Transplantation for Hematologic MalignanciesCompletedNCT01188798Phase 3Results posted
• The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot DropTerminatedNCT01001390Not applicableResults posted
• Learning Impairments Among Survivors of Childhood CancerCompletedNCT00576472Phase 4Results posted
• Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological MalignanciesCompletedNCT00566696Phase 2Results posted
• Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic LeukemiaCompletedNCT00549848Phase 3Results posted
• A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia SurvivorsCompletedNCT00186901Phase 3Results posted
• Therapy for Pediatric Relapsed or Refractory Acute Lymphoblastic LeukemiaCompletedNCT00186875Phase 2Results posted
• HLA-Nonidentical Stem Cell and Natural Killer Cell Transplantation for Children Less the Two Years of Age With Hematologic MalignanciesCompletedNCT00145626Phase 2Results posted
• Therapy for Newly Diagnosed Patients With Acute Lymphoblastic LeukemiaCompletedNCT00137111Phase 3Results posted
• Childhood Cancer Survivors' Affective Response to ExerciseActive, not recruitingNCT05763290
• Characterizing Sleep Among Long-term Survivors of Childhood CancerActive, not recruitingNCT05480904
• Continuous Ambulatory Monitoring to Predict Elevated Risk of Infection in Children With Lymphoblastic Leukemia Undergoing Induction Chemotherapy (CAMPER-ALL)WithdrawnNCT04322084
• Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)Active, not recruitingNCT04105530Not applicable
• Inotuzumab Ozogamicin for Children With MRD Positive CD22+ Lymphoblastic LeukemiaTerminatedNCT03913559Phase 2
• Postural Control Under Different Cognitive Loads in Adult Survivors of Acute Lymphoblastic Leukemia and Age-Matched Healthy IndividualsCompletedNCT03581045
• Treatment With Combination Chemotherapy for Relapsed or Refractory Acute Lymphoblastic LeukemiaTerminatedNCT03515200Phase 1
• Cognitive Intervention at the End of Therapy for Survivors of Childhood ALL Treated on TOTXVICompletedNCT03187977Not applicable
• Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and LymphomaActive, not recruitingNCT03117751Phase 2/3
• Genetic Study of Familial Acute Lymphoblastic LeukemiaCompletedNCT03067584
• Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior TransplantationActive, not recruitingNCT02790515Phase 2
• A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood CancerActive, not recruitingNCT02256137
• Selinexor With Fludarabine and Cytarabine for Treatment of Refractory or Relapsed Leukemia or Myelodysplastic SyndromeCompletedNCT02212561Phase 1
• Transfusional Iron Overload Among Leukemia SurvivorsCompletedNCT01965171
• Computerized Intervention for Amelioration of Cognitive Late Effects Among Childhood Cancer SurvivorsCompletedNCT01217996Not applicable
• A Pediatric Study of a Plerixafor Containing Regimen In Second Allogeneic Stem Cell TransplantationCompletedNCT01068301Phase 1
• Motor Proficiency And Physical Activity in Adult Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)CompletedNCT01047020
• Risk of Psychopathology and Neurocognitive Impairment in Leukemia SurvivorsCompletedNCT01014195
• Genetically Modified Haploidentical Natural Killer Cell Infusions for B-Lineage Acute Lymphoblastic LeukemiaCompletedNCT00995137Phase 1
• Physical Activity to Modify Sequelae and Quality of Life in Childhood Acute Lymphoblastic LeukemiaCompletedNCT00902213Not applicable
• Aerobic and Strengthening Exercise for Acute LeukemiaCompletedNCT00766311Not applicable
• AVN of Weight-Bearing Joints In Patients With Hematologic Malignancies Treated With Dexamethasone Or PrednisoneCompletedNCT00719147
• Irinotecan, Vincristine, and Dexamethasone In Children With Relapsed And/Or Refractory Hematologic MalignanciesCompletedNCT00718757Phase 1
• Pilot Study of Haploidentical Natural Killer Cell Infusions for Poor Prognosis Non-AML Hematologic MalignanciesCompletedNCT00697671Phase 1
• Compassionate Use of Erwinase For Pediatric Patients With Acute Lymphoblastic Leukemia Or Non Hodgkins LymphomaCompletedNCT00693602Phase 1
• Neurologic Morbidity and Disability in Acute Lymphoblastic Leukemia SurvivorsCompletedNCT00664131
• Pilot Study of Expanded, Donor Natural Killer Cell Infusions for Refractory Non-B Lineage Hematologic Malignancies and Solid TumorsCompletedNCT00640796Phase 1
• Treatment of Burkitt Lymphoma/Leukemia and B Large Cell NHLCompletedNCT00187161Phase 2
• Treatment for Patients With Stage III or IV Non-Hodgkin LymphomaCompletedNCT00187122Not applicable
• A Study of Children With Refractory or Relapsed ALLCompletedNCT00187083Phase 3
• Total Therapy Study XIV for Newly Diagnosed Patients With Acute Lymphoblastic LeukemiaTerminatedNCT00187005Phase 3
• Haploidentical Stem Cell Transplantation for Patients With Hematologic MalignanciesCompletedNCT00186823Phase 3
• Stem Cell Transplantation for Patients With Hematologic MalignanciesCompletedNCT00152139Phase 3
• Haploidentical Stem Cell Transplant for Treatment Refractory Hematological MalignanciesCompletedNCT00145613Phase 2
• Stem Cell Transplantation as Immunotherapy for Hematologic MalignanciesCompletedNCT00143559Phase 2