Pfizer: COVID-19 trials

The registry lists 69 COVID-19 studies with Pfizer as lead sponsor. 4 are open to participants now and 39 have results posted.

Phase 1 25Phase 2 11Phase 3 8Phase 4 1No phase 28(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely ImmunocompromisedRecruitingNCT07013474Phase 3
• A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe DiseaseRecruitingNCT06679140Phase 3
• A Study on Paxlovid Once in the Market, to Observe Its Safety and Effectiveness in Patients Who Have a High Chance of Getting Severe COVID-19RecruitingNCT05890612
• EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe DiseaseRecruitingNCT05261139Phase 3
• A US Study to Look at Loss of Work and Healthcare Costs for People Affected With Mild-to-moderate COVID 19 Who Have High Chances of the Disease Becoming SevereCompletedNCT07072793Results posted
• A Study to Learn About the Use of Paxlovid in Patients With COVID-19 in the Kingdom of Bahrain.CompletedNCT06291831Results posted
• A Study to Learn About a Combined COVID-19 and Influenza Shot in Healthy AdultsCompletedNCT06237049Phase 2Results posted
• Effectiveness of BNT162b2 Formulations Using State Vaccine Registry and Insurance Claims DataCompletedNCT06199934Results posted
• Special Investigation for Booster Dose of Comirnaty in Children Ages 6 Months Though 4 YearsCompletedNCT06130410Results posted
• A Study of COVID-19 Patients Receiving Treatment With Nirmatrelvir; Ritonavir in the Kingdom of Saudi ArabiaCompletedNCT06016556Results posted
• A Study to Learn About the Study Medicine Called Nirmatrelvir/Ritonavir in People Who Are Healthy Volunteers Co-administered the Medicine RosuvastatinCompletedNCT05898672Phase 1Results posted
• A Study to Learn About Two or More Vaccines That Are Put Together as One Shot Against Infectious Lung Illnesses, Including COVID-19 and Respiratory Syncytial Virus (RSV).CompletedNCT05886777Phase 2Results posted
• This Study Intends to Describe the Characteristics of Patients Given the Pfizer-BioNTech Bivalent mRNA COVID-19 Vaccine and Any Commercially Available Influenza Vaccines at the Same Time Versus at Different Times.CompletedNCT05858450Results posted
• A Study to Learn About How Itraconazole Affects the Blood Level of Study Medicine (PF-07817883) in Healthy Adults.CompletedNCT05822440Phase 1Results posted
• A Study to Understand the Effect and Safety of the Study Medicine PF-07817883 in Adults Who Have Symptoms of COVID-19 But Are Not HospitalizedCompletedNCT05799495Phase 2Results posted
• A Study to Understand is the COVID-19 Vaccine BNT162b2 is Safe in Indonesia PeopleCompletedNCT05621239Results posted
• A Study to Learn Safety and Blood Levels of PF-07817883 in Healthy PeopleCompletedNCT05580003Phase 1Results posted
• A Study to Learn About a Repeat 5-Day Treatment With the Study Medicines (Called Nirmatrelvir/Ritonavir) in People 12 Years Old or Older With Return of COVID-19 Symptoms and SARS-CoV-2 Positivity After Finishing Treatment With Nirmatrelvir/RitonavirCompletedNCT05567952Phase 2Results posted
• Relative Bioavailability Study of Nirmatrelvir/Ritonavir Oral Powder Relative to the Commercial Tablets and Estimation of the Effect of Food on Bioavailability of the Nirmatrelvir/Ritonavir Oral Powder in Healthy Participants.CompletedNCT05544786Phase 1Results posted
• Relative Bioavailability Study of Nirmatrelvir/Ritonavir 4 Different Fixed Dose Combination Tablets Relative to the Commercial Tablets in Healthy ParticipantsCompletedNCT05525910Phase 1Results posted
• A Study to Measure the Amount of Study Medicine in Blood in Adult Participants With COVID-19 and Severe Kidney DiseaseTerminatedNCT05487040Phase 1Results posted
• A Study to Learn About the Medicine (PF-07321332 or Nirmatrelvir/Ritonavir) in Healthy Lactating WomenCompletedNCT05441215Phase 1Results posted
• A Study to Learn About the Study Medicines (Nirmatrelvir Plus Ritonavir) in People Aged 12 Years or Older With COVID-19 and a Compromised Immune SystemCompletedNCT05438602Phase 2Results posted
• A Study to Learn About the Study Medicine PF-07321332 and Ritonavir in Adult Healthy Chinese Participants.CompletedNCT05339334Phase 1Results posted
• Relative Bioavailability Study of PF-07321332/Ritonavir Oral Powder Relative to the Commercial Tablets in Healthy ParticipantsCompletedNCT05263921Phase 1Results posted
• A Study to Learn About PAXLOVID (a Commercial Medicine) In People With COVID-19CompletedNCT05263908Results posted
• Relative Bioavailability Study of 4 Different Formulations of PF-07321332 Relative to the Commercial Tablet FormulationCompletedNCT05263895Phase 1Results posted
• Food Effect Study to Evaluate the Effect of High-Fat Meal on the Relative Bioavailability of PF-07321332 Boosted With Ritonavir in Healthy Adult ParticipantsCompletedNCT05129475Phase 1Results posted
• PF-07321332/Ritonavir and Ritonavir on Dabigatran Study in Healthy ParticipantsCompletedNCT05064800Phase 1Results posted
• Study to Investigate the Mass Balance, Metabolism, and Excretion of [14C]-PF-07304814 in Healthy ParticipantsCompletedNCT05050682Phase 1Results posted
• A Study of a Potential Oral Treatment to Prevent COVID-19 in Adults Who Are Exposed to Household Member(s) With a Confirmed Symptomatic COVID-19 InfectionCompletedNCT05047601Phase 2/3Results posted
• Drug-Drug Interaction Study to Estimate the Effect of PF-07321332/Ritonavir and Ritonavir on Midazolam in Healthy ParticipantsCompletedNCT05032950Phase 1Results posted
• COVID-19 Vaccination and Breakthrough Infections Among Persons With Immunocompromising Conditions in the United StatesCompletedNCT05020145Results posted
• Evaluation of Protease Inhibition for COVID-19 in Standard-Risk Patients (EPIC-SR).TerminatedNCT05011513Phase 2/3Results posted
• Study to Estimate the Effects of Hepatic Impairment on the Pharmacokinetics (PK) of PF-07321332CompletedNCT05005312Phase 1Results posted
• EPIC-HR: Study of Oral PF-07321332/Ritonavir Compared With Placebo in Nonhospitalized High Risk Adults With COVID-19CompletedNCT04960202Phase 2/3Results posted
• Renal Impairment Study of PF-07321332 Boosted With Ritonavir in Adult Participants With Renal Impairment and in Healthy Participants With Normal Renal Function.CompletedNCT04909853Phase 1Results posted
• Safety and Immunogenicity Study of 20vPnC When Coadministered With a Booster Dose of BNT162b2CompletedNCT04887948Phase 3Results posted
• Special Investigation of COMIRNATY in the Population With Underlying DiseasesCompletedNCT04880447Results posted
• Drug Use Investigation of COMIRNATY Intramuscular InjectionCompletedNCT04815031Results posted
• Acute Respiratory Illness Surveillance (AcRIS) With Mobile Application in a Low-Interventional Decentralized Study.CompletedNCT04748445Results posted
• First-In-Human Study To Evaluate Safety, Tolerability, And Pharmacokinetics Following Single Ascending And Multiple Ascending Doses of PF-07304814 In Hospitalized Participants With COVID-19.CompletedNCT04535167Phase 1Results posted
• Safety and Efficacy Trial of Zavegepant* Intranasal for Hospitalized Patients With COVID-19 Requiring Supplemental OxygenTerminatedNCT04346615Phase 2/3Results posted
• A Study to Learn About COVID-19 Antivirals in People With SARS-CoV-2 Infection From 2023-2026Active, not recruitingNCT07900139
• A Study of How Ibuzatrelvir is Taken up Into the Blood of Healthy Adults After Taking Different Tablets of IbuzatrelvirCompletedNCT07552779Phase 1
• A Study to Learn How Paxlovid [Nirmatrelvir-ritonavir/PF-07321332] Works in COVID-19 Patients Who Are Elderly or Have Medical Conditions.CompletedNCT07261085
• A Study to Learn How the Study Medicine Called Ibuzatrelvir is Taken up Into the Blood in Healthy Chinese AdultsCompletedNCT07235137Phase 1
• A Study to Understand How the Use of Paxlovid Affected Healthcare Use in People With Pre-existing Conditions.CompletedNCT07090486
• A Study to Learn About the Study Medicine Paxlovid (Nirmatrelvir + Ritonavir) in Adults Aged 60 and Older Living in Korean Long-term Care Hospitals Who Have COVID-19CompletedNCT07089680
• A Study to Learn About How Well Yearly Updates to the COVID-19 Vaccine Work to Protect People From COVID-19 and How Much Money People Spend on Healthcare for COVID-19Active, not recruitingNCT06923137
• Secondary Databased Post-marketing Surveillance Study of BNT162b2CompletedNCT06743334
• Estimated Vaccine Effectiveness and Durability of Pfizer/BioNTech 2024-2025 COVID-19 VaccineTerminatedNCT06703190
• A Study to Learn About if the Study Medicine Called Ibuzatrelvir Changes How the Body Process the Other Medicine Dabigatran Etexilate in Healthy AdultsCompletedNCT06693518Phase 1
• Korean Post Marketing Surveillance for Comirnaty Injection (Bretovameran)Active, not recruitingNCT06613984
• A Study to Learn How Renal Impairment Affects the Pharmacokinetics of PF-07817883.CompletedNCT06586216Phase 1
• A Study on 2 Different Combination Tablets of Nirmatrelvir Plus Ritonavir to Compare Them With Marketed Paxlovid in Healthy ParticipantsWithdrawnNCT06397144Phase 1
• A Study to Look at the Health Outcomes of Patients With COVID-19 and Influenza.WithdrawnNCT06163677
• A Study to Learn About Effects of Living With COVID-19 and the Use of the Medicines Nirmatrelvir-Ritonavir in Treating COVID-19.CompletedNCT06085924
• A Study to Learn About the Patients With COVID-19 Prescribed Paxlovid in MoroccoWithdrawnNCT05997485
• A Study to Learn About How Loss of Liver Function Affects the Blood Levels of the Study Medicine Called PF-07817883.CompletedNCT05884554Phase 1
• Use and Effectiveness of COVID-19 Vaccines Using State Vaccine Registries and Insurance Claims DataTerminatedNCT05876377
• A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19WithdrawnNCT05545319Phase 2
• A Study to Learn About the Study Medicine (Nirmatrelvir Plus Ritonavir) in Pregnant Women With COVID-19TerminatedNCT05386472Phase 1
• A Study to Learn About The COVID-19 (Study) Vaccine (Called COMIRNATY) in People That Are Less Than 21 Years Old.Active, not recruitingNCT05295290Phase 4
• Study to Investigate the Mass Balance, Metabolism, and Excretion of [14C]PF-07321332 in Healthy Male Participants.WithdrawnNCT05178654Phase 1
• A Study to Look at the Health Outcomes of Patients With COVID-19 and InfluenzaActive, not recruitingNCT05160636
• Korea Comirnaty Post-marketing SurveillanceActive, not recruitingNCT05032976
• Pfizer-BioNTech COVID-19 Vaccine Effectiveness Study - Kaiser Permanente Southern CaliforniaCompletedNCT04848584
• Safety and Efficacy of Tofacitinib in Hospitalized Participants With COVID-19 Pneumonia Who Are Receiving Standard of Care TherapyWithdrawnNCT04412252Phase 2