Pfizer: Colorectal Neoplasms trials

The registry lists 73 Colorectal Neoplasms studies with Pfizer as lead sponsor. 7 are open to participants now and 31 have results posted.

Phase 1 38Phase 2 27Phase 3 9Phase 4 2No phase 3(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Real-World Treatment Patterns and Effectiveness of Anti-EGFR- and Anti-VEGF-based Therapies in Left-sided RAS Wild-Type Metastatic Colorectal CancerNot yet recruitingNCT07909122
• Tucatinib Continuation StudyNot yet recruitingNCT07768358Phase 4
• A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid TumorsRecruitingNCT07318805Phase 1
• Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal CancerRecruitingNCT07222800Phase 3
• A Study of SGN-CEACAM5C in Adults With Advanced Solid TumorsRecruitingNCT06131840Phase 1
• A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal CancerRecruitingNCT05253651Phase 3
• Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid TumorsRecruitingNCT04557449Phase 2
• Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15CompletedNCT05546476Phase 2Results posted
• Study of PF-07263689 in Participants With Selected Advanced Solid TumorsTerminatedNCT05061537Phase 1Results posted
• Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and AnorexiaCompletedNCT04803305Phase 1Results posted
• A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid TumorsCompletedNCT04672460Phase 1Results posted
• Study to Test the Safety and Tolerability of PF-07209960 in Advanced or Metastatic Solid TumorsTerminatedNCT04628780Phase 1Results posted
• A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal CancerActive, not recruitingNCT04607421Phase 3Results posted
• Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 AlterationsActive, not recruitingNCT04579380Phase 2Results posted
• Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal CancersActive, not recruitingNCT04430738Phase 2Results posted
• Study to Assess the Safety and Tolerability of Repeated Doses of an Investigational New Drug in Patients With Cancer and Cachexia.CompletedNCT04299048Phase 1Results posted
• Study to Test the Safety and Tolerability of PF-07062119 in Patients With Selected Advanced or Metastatic Gastrointestinal Tumors.TerminatedNCT04171141Phase 1Results posted
• PF-06952229 Treatment in Adult Patients With Advanced Solid TumorsTerminatedNCT03685591Phase 1Results posted
• Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal CancerCompletedNCT03043313Phase 2Results posted
• Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal CancerCompletedNCT02928224Phase 3Results posted
• PF-06671008 Dose Escalation Study in Advanced Solid TumorsTerminatedNCT02659631Phase 1Results posted
• A Study Of PF-05212384 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI In Metastatic Colorectal CancerTerminatedNCT01937715Phase 1/2Results posted
• Phase Ib/II Study of Efficacy and Safety of MEK162 and Panitumumab, in Adult mCRC Patients With Mutant or Wild-type RAS TumorsCompletedNCT01927341Phase 1/2Results posted
• A Study Of PF-05212384 Plus Irinotecan Vs Cetuximab Plus Irinotecan In Patients With KRAS And NRAS Wild Type Metastatic Colorectal CancerTerminatedNCT01925274Phase 2Results posted
• Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal CancerCompletedNCT01719380Phase 2Results posted
• A Phase I Study of Oral LGX818 in Adult Patients With Advanced or Metastatic BRAF Mutant MelanomaCompletedNCT01436656Phase 1Results posted
• Figitumumab Combined With Pegvisomant For Advanced Solid TumorsTerminatedNCT00976508Phase 1Results posted
• Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic Breast CancerTerminatedNCT00959946Phase 1/2Results posted
• Study Of Sunitinib With FOLFIRI In Colorectal CancerCompletedNCT00668863Phase 2Results posted
• Study Of Sunitinib In Combination With Folfox In Patients With Colorectal CancerCompletedNCT00631410Phase 1Results posted
• A Study Combining FOLFOX or FOLFIRI With AG-013736 or Bevacizumab (Avastin) in Patients With Metastatic Colorectal Cancer After Failure Of One First Line RegimenCompletedNCT00615056Phase 2Results posted
• Randomized Study Of Sunitinib Plus FOLFOX Versus Bevacizumab Plus FOLFOX In Metastatic Colorectal CancerTerminatedNCT00609622Phase 2Results posted
• Study Of Sunitinib Plus FOLFOX In Patients With Solid TumorsCompletedNCT00599924Phase 1Results posted
• Study Using CP-751,871 In Patients With Stage IV Colorectal Cancer That Has Not Responded To Previous Anti-Cancer TreatmentsCompletedNCT00560560Phase 2Results posted
• Study With AG-013736 Combined With Chemotherapy And Bevacizumab In Patients With Metastatic Colorectal CancerCompletedNCT00460603Phase 1/2Results posted
• Study Of FOLFIRI Chemotherapy With Or Without Sunitinib In Patients With Metastatic Colorectal CancerCompletedNCT00457691Phase 3Results posted
• Comparing Irinotecan and 5 FU/FA To 5-FU/FA After Resection Of Liver Metastases For Colorectal CancerCompletedNCT00143403Phase 3Results posted
• Trial Of Irinotecan In Combination With Three Methods Of Administration Of Fluoropyrimidine.CompletedNCT00101686Phase 3Results posted
• An Observational Study to Learn About the Medicine - BEVACIZUMAB BS [Pfizer] in Colorectal Cancer Patients From Japan.CompletedNCT07527832
• A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene.TerminatedNCT06704724Phase 1
• A Study to Learn About PF-07921585 Alone or With Other Anti-cancer Medicines in People With CancerTerminatedNCT06580938Phase 1
• A Study of SGN-B6A in Chinese Participants With Advanced Solid TumorsCompletedNCT06549816Phase 1
• A Study to Learn About How Different Amounts of the Study Medicine PF-07826390 Act in the Body of People With Cancer When Taken Alone or With Other Anti-cancer Medicines.TerminatedNCT06546553Phase 1
• A Study of SGN-MesoC2 in Advanced Solid TumorsTerminatedNCT06466187Phase 1
• A Study in Advanced/Metastatic Solid Tumors With the Study Medicine (PF-07329640) When Given Alone or In CombinationTerminatedNCT06448364Phase 1
• A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.Active, not recruitingNCT06447662Phase 1
• A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid TumorsTerminatedNCT06285097Phase 1
• A Study of PF-08046052/SGN-EGFRd2 in Advanced Solid TumorsTerminatedNCT05983133Phase 1
• A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid TumorsTerminatedNCT05571839Phase 1
• Safety and Pharmacokinetics of Tucatinib (MK-7119) in Chinese Participants With Cancer (MK-7119-002)Active, not recruitingNCT05382364Phase 1
• A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal CancerActive, not recruitingNCT05217446Phase 2
• A Post-marketing Surveillance to Assess the Safety and Effectiveness of Zirabev in Domestic Patients With Various CancerWithdrawnNCT04889495
• PF-07284892 in Participants With Advanced Solid TumorsTerminatedNCT04800822Phase 1
• A Study of SGN-STNV in Advanced Solid TumorsTerminatedNCT04665921Phase 1
• Study of PF-07265807 in Participants With Metastatic Solid Tumors.TerminatedNCT04458259Phase 1
• A Study of SGN-CD228A in Advanced Solid TumorsTerminatedNCT04042480Phase 1
• A Safety Study of SGN-CD47M in Patients With Solid TumorsTerminatedNCT03957096Phase 1
• Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid TumorsActive, not recruitingNCT03485209Phase 2
• A Safety Study of SGN-2FF for Patients With Advanced Solid TumorsTerminatedNCT02952989Phase 1
• Study of WNT974 in Combination With LGX818 and Cetuximab in Patients With BRAF-mutant Metastatic Colorectal Cancer (mCRC) and Wnt Pathway MutationsCompletedNCT02278133Phase 1/2
• Phase 1 and 2 Study of PX-866 and CetuximabCompletedNCT01252628Phase 1/2
• A Study of ARRY-438162 (MEK162) in Patients With Advanced CancerCompletedNCT00959127Phase 1
• Study to Evaluate the Safety, Tolerability and Efficacy of FOLFOX + CT-011 Versus FOLFOX AloneCompletedNCT00890305Phase 2
• Pharmacogenomics Blood Sampling Protocol For Irinotecan/Fluorouracil/Leucovorin(CPT-11/FU/LV).CompletedNCT00140036Phase 4
• Neoadjuvant Colorectal Cancer With Unresectable Liver MetastasesTerminatedNCT00106054Phase 2
• Study of the GARFT Inhibitor AG2037 in Patients With Metastatic Colorectal Cancer Who Failed TreatmentCompletedNCT00078468Phase 2
• Assessment Of Safety And Efficacy Of SU11248 In Patients With Metastatic Colorectal Cancer Who Have Failed Selected Previous Treatments.CompletedNCT00077987Phase 2
• Study Evaluating EKB-569 in Advanced Colorectal CancerCompletedNCT00072748Phase 2
• Study Evaluating MAC-321 in Colorectal CancerCompletedNCT00063427Phase 2
• For Prevention of Diarrhea in Patients Diagnosed With Metastatic Colorectal Cancer Treated With ChemotherapyTerminatedNCT00037180Phase 2
• A Multicenter Phase 2 Study of CI-1040 in Patients With Advanced Nonsmall-Cell Lung, Breast, Colon and Pancreatic CancerCompletedNCT00034827Phase 2
• Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients Following Surgery for Stage III Colorectal CancerCompletedNCT00026273Phase 3
• Leucovorin and Fluorouracil With or Without SU5416 in Treating Patients With Metastatic Colorectal CancerCompletedNCT00004252Phase 3