Pfizer: Alzheimer Disease trials

The registry lists 101 Alzheimer Disease studies with Pfizer as lead sponsor. 1 are open to participants now and 40 have results posted.

Phase 1 52Phase 2 27Phase 3 17No phase 8(a study in two phases counts in both)

Studies

Page 1 of 2. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Study to Learn How Different Amounts of the Study Medicine Called PF-08161842 Are Tolerated and Act in the Body in Healthy and Older AdultsNot yet recruitingNCT07897708Phase 1
• Clinical Trial In Healthy Volunteers And Health Elderly Volunteers To Evaluate The Safety, Tolerability And Blood Concentration After Single And Multiple Escalating Oral Doses Of PF-06751979.CompletedNCT02793232Phase 1Results posted
• Long-term Safety of Tafamidis in Subjects With Transthyretin CardiomyopathyCompletedNCT02791230Phase 3Results posted
• First-In-Human Study Of Single And Multiple Ascending Doses Of PF-06751979CompletedNCT02509117Phase 1Results posted
• Safety and Efficacy of Tafamidis in Patients With Transthyretin CardiomyopathyCompletedNCT01994889Phase 3Results posted
• Study Evaluating TheSafety And Efficacy Of PF-05212377 Or Placebo In Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms On DonepezilTerminatedNCT01712074Phase 2Results posted
• Open Label Extension Study Evaluating Safety and Tolerability of AAB-003 (PF-05236812) in Subject With Mild to Moderate Alzheimer's DiseaseCompletedNCT01369225Phase 1Results posted
• Long Term Extension Study Evaluating Safety, Tolerability And Immunogenicity Of ACC-001 In Japanese Subjects With Mild To Moderate Alzheimer's DiseaseTerminatedNCT01238991Phase 2Results posted
• Amyloid Imaging And Safety Study Of ACC-001 In Subjects With Early Alzheimer's DiseaseCompletedNCT01227564Phase 2Results posted
• Study Evaluating The Safety Of AAB-003 (PF-05236812) In Subjects With Alzheimer's DiseaseCompletedNCT01193608Phase 1Results posted
• Quality Of Life Assessment In Alzheimer's Disease (AD) Patients Receiving Aricept TabletsCompletedNCT01089582Results posted
• Acute Effects Of Donepezil On Brain Perfusion And Memory In Subjects With Cognitive Impairment And Mild Alzheimer's DiseaseTerminatedNCT01082965Not applicableResults posted
• An Extension To The B1451006 Protocol To Evaluate The Safety and Efficacy of Dimebon In Subjects With Moderate-to-Severe Alzheimer's DiseaseTerminatedNCT01066546Phase 3Results posted
• A Study to Evaluate the Safety, Tolerability, and Blood Levels of PF-03654746 in Subjects With Mild to Moderate Alzheimer's DiseaseTerminatedNCT01028911Phase 1Results posted
• A Long-Term Safety And Tolerability Extension Study Of Bapineuzumab In Alzheimer Disease PatientsTerminatedNCT00998764Phase 3Results posted
• A Long-Term Safety And Tolerability Study Of Bapineuzumab In Alzheimer Disease PatientsTerminatedNCT00996918Phase 3Results posted
• A Brief Study To Evaluate The Safety, Tolerability, And Blood Levels Of Multiple Doses Of PF-044467943 Or Placebo In Combination With Donepezil In Subjects With Mild To Moderate Alzheimer's DiseaseCompletedNCT00988598Phase 1Results posted
• A Study To Evaluate The Abuse Potential Of Single Oral Doses Of Dimebon (Latrepirdine) In Healthy Recreational Polydrug UsersCompletedNCT00975481Phase 1Results posted
• A Long Term Extension Study Evaluating ACC-001 With QS-21 in Subjects With Mild to Moderate Alzheimer's DiseaseTerminatedNCT00960531Phase 2Results posted
• Safety, Tolerability, And Immunogenicity Study Of ACC-001 In Japanese Subjects With Mild To Moderate Alzheimer's DiseaseCompletedNCT00959192Phase 2Results posted
• Long Term Extension Study Evaluating Safety, Tolerability and Immunogenicity Of ACC-001 In Subjects With Mild To Moderate Alzheimer's DiseaseCompletedNCT00955409Phase 2Results posted
• A Multiple Dose Study of PF-04360365 In Patients With Mild to Moderate Alzheimer's DiseaseCompletedNCT00945672Phase 2Results posted
• An Extension To The B1451027 Protocol To Evaluate The Long Term Safety And Tolerability Of Dimebon In Patients With Alzheimer's DiseaseTerminatedNCT00939783Phase 3Results posted
• A Study Of PF-04447943 Compared To Placebo In Subjects With Mild To Moderate Alzheimer's DiseaseCompletedNCT00930059Phase 2Results posted
• Study Evaluating The Long-Term Safety And Efficacy Of Subcutaneous BapineuzumabTerminatedNCT00916617Phase 2Results posted
• A Phase 3 Efficacy Study Of Dimebon In Patients With Moderate To Severe Alzheimer's DiseaseTerminatedNCT00912288Phase 3Results posted
• Study Comparing 3 Dosage Levels Of SAM-531 In Outpatients With Mild To Moderate Alzheimer DiseaseTerminatedNCT00895895Phase 2Results posted
• Non-Interventional Study With Aricept® EvessCompletedNCT00889603Results posted
• Observational Study Of Donepezil In Routine Clinical PracticeTerminatedNCT00843115Results posted
• A Phase 3 Study To Evaluate The Safety And Tolerability Of Dimebon Patients With Mild To Moderate Alzheimer's DiseaseCompletedNCT00838110Phase 3Results posted
• An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Patients With Transthyretin Amyloid PolyneuropathyCompletedNCT00791492Phase 2/3Results posted
• Study Evaluating ACC-001 in Japanese Patients With Mild To Moderate Alzheimer's DiseaseCompletedNCT00752232Phase 2Results posted
• Evaluation of the Efficacy of Varenicline on Cognition, Safety, Tolerability and Pharmacokinetics in Subjects With Mild-to-Moderate Alzheimer's DiseaseCompletedNCT00744978Phase 2Results posted
• Multiple IV Dose Study Of PF-04360365 In Patients With Mild To Moderate Alzheimer's DiseaseCompletedNCT00722046Phase 2Results posted
• Study Evaluating the Safety and Efficacy of Bapineuzumab in Alzheimer Disease PatientsTerminatedNCT00676143Phase 3Results posted
• Study Evaluating The Efficacy And Safety Of Bapineuzumab In Alzheimer Disease PatientsTerminatedNCT00667810Phase 3Results posted
• Study Evaluating Bapineuzumab In Alzheimer Disease SubjectsCompletedNCT00663026Phase 2Results posted
• Study Evaluating ACC-001 In Subjects With Mild To Moderate Alzheimer's DiseaseCompletedNCT00498602Phase 2Results posted
• Study Evaluating Safety, Tolerability, And Immunogenicity Of ACC-001 In Subjects With Mild To Moderate Alzheimer's DiseaseCompletedNCT00479557Phase 2Results posted
• Safety and Efficacy Study of Fx-1006A in Patients With Familial AmyloidosisCompletedNCT00409175Phase 2/3Results posted
• Study Evaluating Single Ascending Doses of AAB-001 Vaccine SAD Japanese Patients With Alzheimers DiseaseCompletedNCT00397891Phase 1Results posted
• A Study To Examine The Distribution Of PF-05212377 In The Brain Of Healthy Volunteer Subjects Using Positron Emission Tomography And A Radioactive Tracer Following Oral Administration Of One Dose Of PF-05212377CompletedNCT02005991Phase 1
• An Extension of the CONCERT Protocol (DIM18)TerminatedNCT01152216Phase 3
• Multiple Intravenous Dose Study Of PF-04360365 In Japanese Patients With Mild To Moderate Alzheimer's DiseaseCompletedNCT01125631Phase 1
• A Study Of Oral PF-01913539 In Patients With Mild To Moderate Alzheimer's DiseaseWithdrawnNCT01066481Phase 2
• Effect of PF-04360365 On ABETA In Patients With Alzheimer's Disease And Healthy VolunteersCompletedNCT01005862Phase 1
• A Study Evaluating The Absorption Of Dimebon Into The Body From A Dimebon Solution Applied To The SkinCompletedNCT00990613Phase 1
• A Study In Healthy Volunteers To Estimate The Pharmacokinetics Of Four Modified-Release Formulations Of Dimebon (Latrepirdine)CompletedNCT00988624Phase 1
• Effect of Aricept on Biomarkers (Acetylcholine, sAPP Alpha) In Cerebrospinal FluidCompletedNCT00987220
• Study Evaluating Potential Interaction Between SAM-531 And Gemfibrozil When Co-AdministeredCompletedNCT00966966Phase 1
• Study Evaluating The Coadministration of Begacestat And DonepezilCompletedNCT00959881Phase 1
• Study Of Single Ascending And Multiple Doses Of PF-04447943 In Japanese Subjects.CompletedNCT00959803Phase 1
• A Phase I Study To Estimate The Effect Of Ketoconazole And Omeprazole On The Pharmacokinetics Of Dimebon In Healthy Subjects Who Are Normal Or Poor CYP2D6 MetabolizersCompletedNCT00931073Phase 1
• Study Evaluating How Quickly And To What Extent The 14-Carbon-SAM-531 Is Absorbed/Converted/Eliminated In Male SubjectsCompletedNCT00906191Phase 1
• Dimebon (PF-01913539)-Digoxin Drug-Drug Interaction Study In Healthy SubjectsCompletedNCT00831506Phase 1
• Safety and Tolerability of Dimebon in Patients on Memantine, and Memantine Plus DonepezilCompletedNCT00829816Phase 1
• Safety and Efficacy Study Evaluating Dimebon in Patients With Mild to Moderate Alzheimer's Disease on DonepezilCompletedNCT00829374Phase 3
• A Phase 1, Randomized, Open-Label, Two-Way Crossover Study To Evaluate The Steady-State Effect Of Dimebon (PF 01913539) On The Single-Dose Pharmacokinetics And Pharmacodynamics Of Warfarin In Healthy SubjectsCompletedNCT00827034Phase 1
• A Phase 1 Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF-01913539] In Japanese And Western Healthy SubjectsCompletedNCT00825084Phase 1
• A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal FunctionCompletedNCT00824590Phase 1
• Multiple Dose Study Evaluating the Safety and Tolerability of NSA-789CompletedNCT00795730Phase 1
• A Phase 1 Study To Evaluate The Effect Of Dimebon On The Pharmacokinetics Of DextromethorphanCompletedNCT00788047Phase 1
• Study Evaluating The Potential Interaction Between Verapamil Immediate Release And SAM-531 When Co-AdministeredCompletedNCT00745576Phase 1
• Study Evaluating PAZ-417 in Cerebrospinal Fluid in Subjects With Alzheimer's DiseaseTerminatedNCT00739037Phase 1
• Single Dose Escalation Study of PF-04360365 In Subjects With Mild To Moderate Alzheimer's DiseaseCompletedNCT00733642Phase 1
• Study Evaluating Safety, Tolerability and Pharmacokinetics of Single and Multiple Dose of SAM-531CompletedNCT00726115Phase 1
• Study Evaluating Safety of GSI 136 in Young and Elderly Japanese MalesCompletedNCT00719394Phase 1
• Study GSI-136 in Healthy Young and Healthy Elderly SubjectsCompletedNCT00718731Phase 1
• Study of Combination Therapy With Dimebon and Donepezil (Aricept) in Patients With Alzheimer's DiseaseTerminatedNCT00704782Phase 2
• Study Evaluating the Safety, Tolerability and Activity of One Dose of PAZ-417 Given to Healthy Japanese SubjectsCompletedNCT00684710Phase 1
• A Safety and Efficacy Study of Oral Dimebon in Patients With Mild-To-Moderate Alzheimer's DiseaseCompletedNCT00675623Phase 3
• A Study of the Efficacy and Safety of Aricept in Patients With Severe Alzheimer's Disease Who Are Living in Skilled Nursing HomesCompletedNCT00630851Phase 3
• A Phase I, Single Dose Study Of PF-04360365 In Japanese Patients With Mild To Moderate Alzheimer's DiseaseCompletedNCT00607308Phase 1
• A Phase 2 Study Evaluating The Efficacy And Safety Of PF 04494700 In Mild To Moderate Alzheimer's DiseaseCompletedNCT00566397Phase 2
• Study Evaluating Potential Pharmacokinetic (PK) Interaction Between Lecozotan and DigoxinCompletedNCT00563732Phase 1
• Study Evaluating Multiple Doses Of GSI-953 Within The Elderly PopulationCompletedNCT00547560Phase 1
• Study Evaluating Effects of SAM-531 on Sleep Electroencephalogram (EEG) and Quantitative Wake EEG in Healthy SubjectsCompletedNCT00519298Phase 1
• Study Evaluating the Effect of Lecozotan SR on the QTc IntervalCompletedNCT00499642Phase 1
• Study Evaluating Safety, Tolerability, Pharmacokinetics and 5 HT1A Receptor OccupancyCompletedNCT00499200Phase 1
• Study Comparing Lecozotan SR Two 5-mg Tablets Vs. Lecozotan SR One 10-mg Tablet in Healthy SubjectsCompletedNCT00494962Phase 1
• A Randomized, Placebo-Controlled Trial to Examine the Efficacy of Oral Donepezil in Subjects With MCICompletedNCT00483028Not applicable
• Study Evaluating the Safety,Tolerability, PK and PD of SAM-531 in the Subjects With Mild to Moderate Alzheimer's DiseaseCompletedNCT00481520Phase 2
• Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of SAM-531 in Healthy Young and Elderly SubjectsCompletedNCT00480818Phase 1
• Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAM-315 in Healthy Japanese MalesCompletedNCT00480467Phase 1
• Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAM-531 in Healthy SubjectsCompletedNCT00479700Phase 1
• Study Evaluating the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of SAM-315 in Healthy AdultsCompletedNCT00479440Phase 1
• Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of SAM-531CompletedNCT00479349Phase 1
• Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAM-531 in Healthy Japanese MalesCompletedNCT00479297Phase 1
• Study Evaluating GSI-953 in Healthy Young and Alzheimer's PatientsCompletedNCT00479219Phase 1
• Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAM-315TerminatedNCT00474552Phase 1
• Combining a Caregiver Intervention With Aricept Treatment for Mild to Moderate Alzheimer's DiseaseCompletedNCT00467766Not applicable
• A Phase I, Single IV Dose Of PF-04360365 In Adults With Mild To Moderate Alzheimer's DiseaseCompletedNCT00455000Phase 1
• Single Ascending Dose Study of SRA-444 in Healthy SubjectsCompletedNCT00452504Phase 1
• Study Evaluating the Safety and Pharmacokinetics of a Single Dose of GSI-953CompletedNCT00441987Phase 1
• Double-blind, Placebo-controlled Study of Oral Dimebon in Subjects With Mild to Moderate Alzheimer's DiseaseCompletedNCT00377715Phase 2
• Study Evaluating the Safety of Lecozotan SR in Healthy Young and Elderly SubjectsCompletedNCT00366483Phase 1
• Study Evaluating PAZ-417 in Healthy Young/ElderlyCompletedNCT00366288
• Study Evaluating the Safety, Tolerability, and Efficacy of Lecozotan SR in Outpatients With Alzheimer's DiseaseCompletedNCT00277810Phase 2/3
• Study Evaluating Lecozotan SR in Mild to Moderate Alzheimer's Disease (AD)CompletedNCT00151398Phase 2
• Study Evaluating SRA-333 in Mild to Moderate Alzheimer's Disease (AD)CompletedNCT00151333Phase 2